Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research...

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Autores principales:	Jiří Podlaha, Kräuff Schwanhaeuser
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	adiponectin experimental surgery pre-clinical trial vascular prosthesis. Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/68897a912d1c4a82862e2b40e97be28d
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spelling	oai:doaj.org-article:68897a912d1c4a82862e2b40e97be28d2021-11-17T21:27:52ZExperimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep1820-744810.2478/acve-2014-0040https://doaj.org/article/68897a912d1c4a82862e2b40e97be28d2014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0040https://doaj.org/toc/1820-7448Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.Jiří PodlahaKräuff SchwanhaeuserSciendoarticleadiponectinexperimental surgerypre-clinical trialvascular prosthesis.Veterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 426-437 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiponectin experimental surgery pre-clinical trial vascular prosthesis. Veterinary medicine SF600-1100
spellingShingle	adiponectin experimental surgery pre-clinical trial vascular prosthesis. Veterinary medicine SF600-1100 Jiří Podlaha Kräuff Schwanhaeuser Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
description	Despite medical advancements, the development of an ideal vascular prosthesis still poses a great challenge. In this study the researchers tried to test and verify the characteristics of a new type of vascular prosthesis, using adiponectin (Adipograft Ra 1vk 7/350) developed at the Knitting Research Institute, a.s. Brno. Two types of vascular prostheses (12 with adiponectin and 6 as a control without adiponectin) were implanted in nine healthy 4-year-old Merino sheep. The implantation site was the common carotid artery and the length of the implant was 10 cm. We applied the theory of the protected coagulum, whereby all sheep received antibiotics as a prophylactic measure. A Doppler U.S. was performed before finishing each operation, in order to verify the patency of the prostheses. Each animal was followed up during the whole study and the prostheses were extirpated on days 30 and 100 (1 and 3 months). It was observed that all prostheses coated with adiponectin showed patency after extirpation. The lumen implants were of a consistent thickness of 7 mm. Histological study of the implanted prostheses confirmed a quick, high quality, healing. Experimental vascular prostheses coated with adiponectin appeared to be successful in clinical practice. The researchers think that Adipograft Ra 1vk 7/350 can be a turning point in the development of vascular prostheses, due to its patency and quick healing.
format	article
author	Jiří Podlaha Kräuff Schwanhaeuser
author_facet	Jiří Podlaha Kräuff Schwanhaeuser
author_sort	Jiří Podlaha
title	Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
title_short	Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
title_full	Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
title_fullStr	Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
title_full_unstemmed	Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep
title_sort	experimental assessment of a new type of vascular prostheses with adiponectin (adipograft ra 1vk 7/350) on sheep
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/68897a912d1c4a82862e2b40e97be28d
work_keys_str_mv	AT jiripodlaha experimentalassessmentofanewtypeofvascularprostheseswithadiponectinadipograftra1vk7350onsheep AT krauffschwanhaeuser experimentalassessmentofanewtypeofvascularprostheseswithadiponectinadipograftra1vk7350onsheep
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Experimental Assessment of a New Type of Vascular Prostheses with Adiponectin (Adipograft Ra 1Vk 7/350) on Sheep

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