Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1

Cell invasion is required for several physiological processes but it is unknown if stem cells induce invasiveness in other cells. Here, the authors show that human stem cells secrete insulin-like growth factor, which in turn activates the mTORC1 pathway, initiating invasive behaviour and attracting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margit Rosner, Ha Thi Thanh Pham, Richard Moriggl, Markus Hengstschläger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/688d330f9d6446e598e5c169d4a45f48
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:688d330f9d6446e598e5c169d4a45f48
record_format	dspace
spelling	oai:doaj.org-article:688d330f9d6446e598e5c169d4a45f482021-12-02T14:41:58ZHuman stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC110.1038/s41467-017-00661-x2041-1723https://doaj.org/article/688d330f9d6446e598e5c169d4a45f482017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00661-xhttps://doaj.org/toc/2041-1723Cell invasion is required for several physiological processes but it is unknown if stem cells induce invasiveness in other cells. Here, the authors show that human stem cells secrete insulin-like growth factor, which in turn activates the mTORC1 pathway, initiating invasive behaviour and attracting other cells.Margit RosnerHa Thi Thanh PhamRichard MorigglMarkus HengstschlägerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Margit Rosner Ha Thi Thanh Pham Richard Moriggl Markus Hengstschläger Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
description	Cell invasion is required for several physiological processes but it is unknown if stem cells induce invasiveness in other cells. Here, the authors show that human stem cells secrete insulin-like growth factor, which in turn activates the mTORC1 pathway, initiating invasive behaviour and attracting other cells.
format	article
author	Margit Rosner Ha Thi Thanh Pham Richard Moriggl Markus Hengstschläger
author_facet	Margit Rosner Ha Thi Thanh Pham Richard Moriggl Markus Hengstschläger
author_sort	Margit Rosner
title	Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
title_short	Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
title_full	Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
title_fullStr	Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
title_full_unstemmed	Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1
title_sort	human stem cells alter the invasive properties of somatic cells via paracrine activation of mtorc1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/688d330f9d6446e598e5c169d4a45f48
work_keys_str_mv	AT margitrosner humanstemcellsaltertheinvasivepropertiesofsomaticcellsviaparacrineactivationofmtorc1 AT hathithanhpham humanstemcellsaltertheinvasivepropertiesofsomaticcellsviaparacrineactivationofmtorc1 AT richardmoriggl humanstemcellsaltertheinvasivepropertiesofsomaticcellsviaparacrineactivationofmtorc1 AT markushengstschlager humanstemcellsaltertheinvasivepropertiesofsomaticcellsviaparacrineactivationofmtorc1
_version_	1718389812708245504

Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1

Ejemplares similares