Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1

Cell invasion is required for several physiological processes but it is unknown if stem cells induce invasiveness in other cells. Here, the authors show that human stem cells secrete insulin-like growth factor, which in turn activates the mTORC1 pathway, initiating invasive behaviour and attracting...

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Bibliographic Details
Main Authors: Margit Rosner, Ha Thi Thanh Pham, Richard Moriggl, Markus Hengstschläger
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/688d330f9d6446e598e5c169d4a45f48
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