Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis

The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice...

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Autores principales:	Neil P. Dufton, Claire R. Peghaire, Lourdes Osuna-Almagro, Claudio Raimondi, Viktoria Kalna, Abhishek Chauhan, Gwilym Webb, Youwen Yang, Graeme M. Birdsey, Patricia Lalor, Justin C. Mason, David H. Adams, Anna M. Randi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d6
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spelling	oai:doaj.org-article:688d3e51bd6e4384bf9ccbf1181bb7d62021-12-02T14:42:08ZDynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis10.1038/s41467-017-01169-02041-1723https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01169-0https://doaj.org/toc/2041-1723The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent mechanism.Neil P. DuftonClaire R. PeghaireLourdes Osuna-AlmagroClaudio RaimondiViktoria KalnaAbhishek ChauhanGwilym WebbYouwen YangGraeme M. BirdseyPatricia LalorJustin C. MasonDavid H. AdamsAnna M. RandiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
description	The transcription factor ERG is key to endothelial lineage specification and vascular homeostasis. Here the authors show that ERG balances TGFβ signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent mechanism.
format	article
author	Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi
author_facet	Neil P. Dufton Claire R. Peghaire Lourdes Osuna-Almagro Claudio Raimondi Viktoria Kalna Abhishek Chauhan Gwilym Webb Youwen Yang Graeme M. Birdsey Patricia Lalor Justin C. Mason David H. Adams Anna M. Randi
author_sort	Neil P. Dufton
title	Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
title_short	Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
title_full	Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
title_fullStr	Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
title_full_unstemmed	Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis
title_sort	dynamic regulation of canonical tgfβ signalling by endothelial transcription factor erg protects from liver fibrogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/688d3e51bd6e4384bf9ccbf1181bb7d6
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Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis

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