Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3 1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Shenyang, 3Institute of Biomedical E...

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Autores principales:	Yu Z, Yu M, Zhou Z, Zhang Z, Du B, Xiong Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/68907c73038c4950944d98884c384779
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spelling	oai:doaj.org-article:68907c73038c4950944d98884c3847792021-12-02T05:04:17ZNovel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane1178-2013https://doaj.org/article/68907c73038c4950944d98884c3847792014-07-01T00:00:00Zhttp://www.dovepress.com/novel-flower-shaped-albumin-particles-as-controlled-release-carriers-f-a17429https://doaj.org/toc/1178-2013 Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3 1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Shenyang, 3Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Biomedical Material of Tianjin, Tianjin, People’s Republic of China *These authors contributed equallyto this work Abstract: Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 µm to 100 µm, and most were 50–80 µm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment. Keywords: bovine serum albumin (BSA), controlled release, local delivery, round-window membraneYu ZYu MZhou ZZhang ZDu BXiong QDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 3193-3201 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yu Z Yu M Zhou Z Zhang Z Du B Xiong Q Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
description	Zhan Yu,1,* Min Yu,2,* Zhimin Zhou,3 Zhibao Zhang,3 Bo Du,3 Qingqing Xiong3 1Second Artillery General Hospital, Beijing, 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, College of Basic Medicine, China Medical University, Shenyang, 3Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Biomedical Material of Tianjin, Tianjin, People’s Republic of China *These authors contributed equallyto this work Abstract: Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 µm to 100 µm, and most were 50–80 µm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment. Keywords: bovine serum albumin (BSA), controlled release, local delivery, round-window membrane
format	article
author	Yu Z Yu M Zhou Z Zhang Z Du B Xiong Q
author_facet	Yu Z Yu M Zhou Z Zhang Z Du B Xiong Q
author_sort	Yu Z
title	Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
title_short	Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
title_full	Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
title_fullStr	Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
title_full_unstemmed	Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
title_sort	novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/68907c73038c4950944d98884c384779
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Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

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