Elevated levels of cortisol in hair precede acute myocardial infarction

Abstract Long term stress exposure is typical for modern societies and might trigger different diseases. This case–control study reveals that persons who had suffered an acute myocardial infarction (AMI) had elevated cortisol concentrations in the month before the acute event. Middle-aged patients a...

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Autores principales:	Tomas Faresjö, Susanna Strömberg, Mike Jones, Andreas Stomby, Jan-Erik Karlsson, Carl Johan Östgren, Åshild Faresjö, Elvar Theodorsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/689192e91bf74d9b8b1d715f3a9881e6
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spelling	oai:doaj.org-article:689192e91bf74d9b8b1d715f3a9881e62021-12-02T15:12:47ZElevated levels of cortisol in hair precede acute myocardial infarction10.1038/s41598-020-80559-92045-2322https://doaj.org/article/689192e91bf74d9b8b1d715f3a9881e62020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80559-9https://doaj.org/toc/2045-2322Abstract Long term stress exposure is typical for modern societies and might trigger different diseases. This case–control study reveals that persons who had suffered an acute myocardial infarction (AMI) had elevated cortisol concentrations in the month before the acute event. Middle-aged patients admitted to cardiology clinics with acute myocardial infarction (AMI) (n = 174) were compared to 3156 controls from a population-based cohort in southeast Sweden. The median Hair Cortisol Concentrations (HCC) for those who had suffered an AMI was 53.2 pg/mg compared to 22.2 pg/mg for the control group (p < 0.001). In bivariate analysis, higher levels of HCC were strongly (OR = 5.69) and statistically significantly associated with current AMI status. The discrimination of cases with AMI from controls remained statistically significant (OR = 5.04) even after controlling for established cardiovascular risk factors in a multivariate analysis. Middle-aged persons with acute myocardial infarction had significantly elevated cortisol levels during the month before the cardiac event. This was evident for both men and women. The biomarker cortisol concentration was independently and statistically significantly related to AMI. Chronic stress seems to be a new promising risk factor for AMI.Tomas FaresjöSusanna StrömbergMike JonesAndreas StombyJan-Erik KarlssonCarl Johan ÖstgrenÅshild FaresjöElvar TheodorssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomas Faresjö Susanna Strömberg Mike Jones Andreas Stomby Jan-Erik Karlsson Carl Johan Östgren Åshild Faresjö Elvar Theodorsson Elevated levels of cortisol in hair precede acute myocardial infarction
description	Abstract Long term stress exposure is typical for modern societies and might trigger different diseases. This case–control study reveals that persons who had suffered an acute myocardial infarction (AMI) had elevated cortisol concentrations in the month before the acute event. Middle-aged patients admitted to cardiology clinics with acute myocardial infarction (AMI) (n = 174) were compared to 3156 controls from a population-based cohort in southeast Sweden. The median Hair Cortisol Concentrations (HCC) for those who had suffered an AMI was 53.2 pg/mg compared to 22.2 pg/mg for the control group (p < 0.001). In bivariate analysis, higher levels of HCC were strongly (OR = 5.69) and statistically significantly associated with current AMI status. The discrimination of cases with AMI from controls remained statistically significant (OR = 5.04) even after controlling for established cardiovascular risk factors in a multivariate analysis. Middle-aged persons with acute myocardial infarction had significantly elevated cortisol levels during the month before the cardiac event. This was evident for both men and women. The biomarker cortisol concentration was independently and statistically significantly related to AMI. Chronic stress seems to be a new promising risk factor for AMI.
format	article
author	Tomas Faresjö Susanna Strömberg Mike Jones Andreas Stomby Jan-Erik Karlsson Carl Johan Östgren Åshild Faresjö Elvar Theodorsson
author_facet	Tomas Faresjö Susanna Strömberg Mike Jones Andreas Stomby Jan-Erik Karlsson Carl Johan Östgren Åshild Faresjö Elvar Theodorsson
author_sort	Tomas Faresjö
title	Elevated levels of cortisol in hair precede acute myocardial infarction
title_short	Elevated levels of cortisol in hair precede acute myocardial infarction
title_full	Elevated levels of cortisol in hair precede acute myocardial infarction
title_fullStr	Elevated levels of cortisol in hair precede acute myocardial infarction
title_full_unstemmed	Elevated levels of cortisol in hair precede acute myocardial infarction
title_sort	elevated levels of cortisol in hair precede acute myocardial infarction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/689192e91bf74d9b8b1d715f3a9881e6
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Elevated levels of cortisol in hair precede acute myocardial infarction

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