A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions and that tetracycline action is via direct perturbat...

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Autores principales:	Michaela Wenzel, Marien P. Dekker, Biwen Wang, Maroeska J. Burggraaf, Wilbert Bitter, Jan R. T. van Weering, Leendert W. Hamoen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c1
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spelling	oai:doaj.org-article:6891a8b700bc4b0d86ca8c303d7203c12021-12-02T13:33:44ZA flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline10.1038/s42003-021-01809-82399-3642https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c12021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01809-8https://doaj.org/toc/2399-3642Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions and that tetracycline action is via direct perturbation of bacterial cell membrane in addition to its known ribosome inhibition activity.Michaela WenzelMarien P. DekkerBiwen WangMaroeska J. BurggraafWilbert BitterJan R. T. van WeeringLeendert W. HamoenNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michaela Wenzel Marien P. Dekker Biwen Wang Maroeska J. Burggraaf Wilbert Bitter Jan R. T. van Weering Leendert W. Hamoen A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
description	Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions and that tetracycline action is via direct perturbation of bacterial cell membrane in addition to its known ribosome inhibition activity.
format	article
author	Michaela Wenzel Marien P. Dekker Biwen Wang Maroeska J. Burggraaf Wilbert Bitter Jan R. T. van Weering Leendert W. Hamoen
author_facet	Michaela Wenzel Marien P. Dekker Biwen Wang Maroeska J. Burggraaf Wilbert Bitter Jan R. T. van Weering Leendert W. Hamoen
author_sort	Michaela Wenzel
title	A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
title_short	A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
title_full	A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
title_fullStr	A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
title_full_unstemmed	A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
title_sort	flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c1
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A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

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