Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune response in a preclinical cancer model.

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Autores principales:	Tian-Yu Song, Min Long, Hai-Xin Zhao, Miao-Wen Zou, Hong-Jie Fan, Yang Liu, Chen-Lu Geng, Min-Fang Song, Yu-Feng Liu, Jun-Yi Chen, Yu-Lin Yang, Wen-Rong Zhou, Da-Wei Huang, Bo Peng, Zhen-Gang Peng, Yong Cang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6892ee3856f549c5b325b419289c5910
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spelling	oai:doaj.org-article:6892ee3856f549c5b325b419289c59102021-12-05T12:22:35ZTumor evolution selectively inactivates the core microRNA machinery for immune evasion10.1038/s41467-021-27331-32041-1723https://doaj.org/article/6892ee3856f549c5b325b419289c59102021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27331-3https://doaj.org/toc/2041-1723Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune response in a preclinical cancer model.Tian-Yu SongMin LongHai-Xin ZhaoMiao-Wen ZouHong-Jie FanYang LiuChen-Lu GengMin-Fang SongYu-Feng LiuJun-Yi ChenYu-Lin YangWen-Rong ZhouDa-Wei HuangBo PengZhen-Gang PengYong CangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tian-Yu Song Min Long Hai-Xin Zhao Miao-Wen Zou Hong-Jie Fan Yang Liu Chen-Lu Geng Min-Fang Song Yu-Feng Liu Jun-Yi Chen Yu-Lin Yang Wen-Rong Zhou Da-Wei Huang Bo Peng Zhen-Gang Peng Yong Cang Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
description	Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune response in a preclinical cancer model.
format	article
author	Tian-Yu Song Min Long Hai-Xin Zhao Miao-Wen Zou Hong-Jie Fan Yang Liu Chen-Lu Geng Min-Fang Song Yu-Feng Liu Jun-Yi Chen Yu-Lin Yang Wen-Rong Zhou Da-Wei Huang Bo Peng Zhen-Gang Peng Yong Cang
author_facet	Tian-Yu Song Min Long Hai-Xin Zhao Miao-Wen Zou Hong-Jie Fan Yang Liu Chen-Lu Geng Min-Fang Song Yu-Feng Liu Jun-Yi Chen Yu-Lin Yang Wen-Rong Zhou Da-Wei Huang Bo Peng Zhen-Gang Peng Yong Cang
author_sort	Tian-Yu Song
title	Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
title_short	Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
title_full	Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
title_fullStr	Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
title_full_unstemmed	Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
title_sort	tumor evolution selectively inactivates the core microrna machinery for immune evasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6892ee3856f549c5b325b419289c5910
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Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

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