Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Tumor evolution selectively inactivates the core microRNA machinery for immune evasion

Dysregulation of the microRNA machinery has crucial roles in cancer development. Here the authors show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO2, confers resistance to T cell-mediated immune response in a preclinical cancer model.

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Bibliographic Details
Main Authors: Tian-Yu Song, Min Long, Hai-Xin Zhao, Miao-Wen Zou, Hong-Jie Fan, Yang Liu, Chen-Lu Geng, Min-Fang Song, Yu-Feng Liu, Jun-Yi Chen, Yu-Lin Yang, Wen-Rong Zhou, Da-Wei Huang, Bo Peng, Zhen-Gang Peng, Yong Cang
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/6892ee3856f549c5b325b419289c5910
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https://doaj.org/article/6892ee3856f549c5b325b419289c5910

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