ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail

Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex and explain how ASPP2 can distinguish between PP1 i...

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Autores principales:	M. Teresa Bertran, Stéphane Mouilleron, Yanxiang Zhou, Rakhi Bajaj, Federico Uliana, Ganesan Senthil Kumar, Audrey van Drogen, Rebecca Lee, Jennifer J. Banerjee, Simon Hauri, Nicola O’Reilly, Matthias Gstaiger, Rebecca Page, Wolfgang Peti, Nicolas Tapon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6895486193a040a6ada179998498e708
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spelling	oai:doaj.org-article:6895486193a040a6ada179998498e7082021-12-02T14:39:42ZASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail10.1038/s41467-019-08686-02041-1723https://doaj.org/article/6895486193a040a6ada179998498e7082019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08686-0https://doaj.org/toc/2041-1723Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex and explain how ASPP2 can distinguish between PP1 isoforms.M. Teresa BertranStéphane MouilleronYanxiang ZhouRakhi BajajFederico UlianaGanesan Senthil KumarAudrey van DrogenRebecca LeeJennifer J. BanerjeeSimon HauriNicola O’ReillyMatthias GstaigerRebecca PageWolfgang PetiNicolas TaponNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Teresa Bertran Stéphane Mouilleron Yanxiang Zhou Rakhi Bajaj Federico Uliana Ganesan Senthil Kumar Audrey van Drogen Rebecca Lee Jennifer J. Banerjee Simon Hauri Nicola O’Reilly Matthias Gstaiger Rebecca Page Wolfgang Peti Nicolas Tapon ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
description	Serine/threonine phosphatases such as PP1 associate with a large array of subunit proteins, such as ASPP (apoptosis-stimulating protein of p53) to achieve selective targeting. Here authors solved the crystal structure of the human ASPP2/PP1 complex and explain how ASPP2 can distinguish between PP1 isoforms.
format	article
author	M. Teresa Bertran Stéphane Mouilleron Yanxiang Zhou Rakhi Bajaj Federico Uliana Ganesan Senthil Kumar Audrey van Drogen Rebecca Lee Jennifer J. Banerjee Simon Hauri Nicola O’Reilly Matthias Gstaiger Rebecca Page Wolfgang Peti Nicolas Tapon
author_facet	M. Teresa Bertran Stéphane Mouilleron Yanxiang Zhou Rakhi Bajaj Federico Uliana Ganesan Senthil Kumar Audrey van Drogen Rebecca Lee Jennifer J. Banerjee Simon Hauri Nicola O’Reilly Matthias Gstaiger Rebecca Page Wolfgang Peti Nicolas Tapon
author_sort	M. Teresa Bertran
title	ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
title_short	ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
title_full	ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
title_fullStr	ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
title_full_unstemmed	ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail
title_sort	aspp proteins discriminate between pp1 catalytic subunits through their sh3 domain and the pp1 c-tail
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6895486193a040a6ada179998498e708
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ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail

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