Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt

Abstract Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifyi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ulf K. Radunski, Johannes Kluwe, Malte Klein, Antonio Galante, Gunnar K. Lund, Christoph Sinning, Sebastian Bohnen, Enver Tahir, Jitka Starekova, Peter Bannas, Christian Stehning, Gerhard Adam, Ansgar W. Lohse, Stefan Blankenberg, Kai Muellerleile, Daniel Benten
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6896c949242d4ad3a8f336cdb3d3b97e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6896c949242d4ad3a8f336cdb3d3b97e
record_format	dspace
spelling	oai:doaj.org-article:6896c949242d4ad3a8f336cdb3d3b97e2021-12-02T17:40:49ZCardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt10.1038/s41598-021-92064-82045-2322https://doaj.org/article/6896c949242d4ad3a8f336cdb3d3b97e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92064-8https://doaj.org/toc/2045-2322Abstract Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170–245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38–51) to 65 (51–73) g/m2 (P = < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.Ulf K. RadunskiJohannes KluweMalte KleinAntonio GalanteGunnar K. LundChristoph SinningSebastian BohnenEnver TahirJitka StarekovaPeter BannasChristian StehningGerhard AdamAnsgar W. LohseStefan BlankenbergKai MuellerleileDaniel BentenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ulf K. Radunski Johannes Kluwe Malte Klein Antonio Galante Gunnar K. Lund Christoph Sinning Sebastian Bohnen Enver Tahir Jitka Starekova Peter Bannas Christian Stehning Gerhard Adam Ansgar W. Lohse Stefan Blankenberg Kai Muellerleile Daniel Benten Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
description	Abstract Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170–245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38–51) to 65 (51–73) g/m2 (P = < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.
format	article
author	Ulf K. Radunski Johannes Kluwe Malte Klein Antonio Galante Gunnar K. Lund Christoph Sinning Sebastian Bohnen Enver Tahir Jitka Starekova Peter Bannas Christian Stehning Gerhard Adam Ansgar W. Lohse Stefan Blankenberg Kai Muellerleile Daniel Benten
author_facet	Ulf K. Radunski Johannes Kluwe Malte Klein Antonio Galante Gunnar K. Lund Christoph Sinning Sebastian Bohnen Enver Tahir Jitka Starekova Peter Bannas Christian Stehning Gerhard Adam Ansgar W. Lohse Stefan Blankenberg Kai Muellerleile Daniel Benten
author_sort	Ulf K. Radunski
title	Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
title_short	Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
title_full	Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
title_fullStr	Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
title_full_unstemmed	Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
title_sort	cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6896c949242d4ad3a8f336cdb3d3b97e
work_keys_str_mv	AT ulfkradunski cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT johanneskluwe cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT malteklein cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT antoniogalante cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT gunnarklund cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT christophsinning cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT sebastianbohnen cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT envertahir cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT jitkastarekova cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT peterbannas cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT christianstehning cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT gerhardadam cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT ansgarwlohse cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT stefanblankenberg cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT kaimuellerleile cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt AT danielbenten cardiovascularmagneticresonancedemonstratesstructuralcardiacchangesfollowingtransjugularintrahepaticportosystemicshunt
_version_	1718379710481694720

Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt

Ejemplares similares