Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

Beta3-adrenergic receptor (b3-AR) signaling in response to cold activates adipose tissue thermogenesis. Here the authors identify the transcription factor FoxP1 as a direct negative regulator of b3-AR expression and show that loss of FoxP1 leads to enhanced development of thermogenic adipose tissue.

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Detalles Bibliográficos
Autores principales:	Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang, Xizhi Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/689791cc9dd840608a5f0954753589ef
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spelling	oai:doaj.org-article:689791cc9dd840608a5f0954753589ef2021-12-02T16:57:20ZFoxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization10.1038/s41467-019-12988-82041-1723https://doaj.org/article/689791cc9dd840608a5f0954753589ef2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12988-8https://doaj.org/toc/2041-1723Beta3-adrenergic receptor (b3-AR) signaling in response to cold activates adipose tissue thermogenesis. Here the authors identify the transcription factor FoxP1 as a direct negative regulator of b3-AR expression and show that loss of FoxP1 leads to enhanced development of thermogenic adipose tissue.Pei LiuSixia HuangShifeng LingShuqin XuFuhua WangWei ZhangRujiang ZhouLin HeXuechun XiaZhengju YaoYing FanNiansong WangCongxia HuXiaodong ZhaoHaley O. TuckerJiqiu WangXizhi GuoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pei Liu Sixia Huang Shifeng Ling Shuqin Xu Fuhua Wang Wei Zhang Rujiang Zhou Lin He Xuechun Xia Zhengju Yao Ying Fan Niansong Wang Congxia Hu Xiaodong Zhao Haley O. Tucker Jiqiu Wang Xizhi Guo Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
description	Beta3-adrenergic receptor (b3-AR) signaling in response to cold activates adipose tissue thermogenesis. Here the authors identify the transcription factor FoxP1 as a direct negative regulator of b3-AR expression and show that loss of FoxP1 leads to enhanced development of thermogenic adipose tissue.
format	article
author	Pei Liu Sixia Huang Shifeng Ling Shuqin Xu Fuhua Wang Wei Zhang Rujiang Zhou Lin He Xuechun Xia Zhengju Yao Ying Fan Niansong Wang Congxia Hu Xiaodong Zhao Haley O. Tucker Jiqiu Wang Xizhi Guo
author_facet	Pei Liu Sixia Huang Shifeng Ling Shuqin Xu Fuhua Wang Wei Zhang Rujiang Zhou Lin He Xuechun Xia Zhengju Yao Ying Fan Niansong Wang Congxia Hu Xiaodong Zhao Haley O. Tucker Jiqiu Wang Xizhi Guo
author_sort	Pei Liu
title	Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
title_short	Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
title_full	Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
title_fullStr	Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
title_full_unstemmed	Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
title_sort	foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-ar desensitization
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/689791cc9dd840608a5f0954753589ef
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Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

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