Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

Beta3-adrenergic receptor (b3-AR) signaling in response to cold activates adipose tissue thermogenesis. Here the authors identify the transcription factor FoxP1 as a direct negative regulator of b3-AR expression and show that loss of FoxP1 leads to enhanced development of thermogenic adipose tissue.

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Bibliographic Details
Main Authors: Pei Liu, Sixia Huang, Shifeng Ling, Shuqin Xu, Fuhua Wang, Wei Zhang, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang, Xizhi Guo
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/689791cc9dd840608a5f0954753589ef
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