Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion...

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Autores principales:	Martina Schweiger, Matthias Romauch, Renate Schreiber, Gernot F. Grabner, Sabrina Hütter, Petra Kotzbeck, Pia Benedikt, Thomas O. Eichmann, Sohsuke Yamada, Oskar Knittelfelder, Clemens Diwoky, Carina Doler, Nicole Mayer, Werner De Cecco, Rolf Breinbauer, Robert Zimmermann, Rudolf Zechner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6897b936ca4b4463ba1c491fe09495d6
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spelling	oai:doaj.org-article:6897b936ca4b4463ba1c491fe09495d62021-12-02T15:38:32ZPharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice10.1038/ncomms148592041-1723https://doaj.org/article/6897b936ca4b4463ba1c491fe09495d62017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14859https://doaj.org/toc/2041-1723The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion ofAtgl.Martina SchweigerMatthias RomauchRenate SchreiberGernot F. GrabnerSabrina HütterPetra KotzbeckPia BenediktThomas O. EichmannSohsuke YamadaOskar KnittelfelderClemens DiwokyCarina DolerNicole MayerWerner De CeccoRolf BreinbauerRobert ZimmermannRudolf ZechnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Schweiger Matthias Romauch Renate Schreiber Gernot F. Grabner Sabrina Hütter Petra Kotzbeck Pia Benedikt Thomas O. Eichmann Sohsuke Yamada Oskar Knittelfelder Clemens Diwoky Carina Doler Nicole Mayer Werner De Cecco Rolf Breinbauer Robert Zimmermann Rudolf Zechner Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
description	The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion ofAtgl.
format	article
author	Martina Schweiger Matthias Romauch Renate Schreiber Gernot F. Grabner Sabrina Hütter Petra Kotzbeck Pia Benedikt Thomas O. Eichmann Sohsuke Yamada Oskar Knittelfelder Clemens Diwoky Carina Doler Nicole Mayer Werner De Cecco Rolf Breinbauer Robert Zimmermann Rudolf Zechner
author_facet	Martina Schweiger Matthias Romauch Renate Schreiber Gernot F. Grabner Sabrina Hütter Petra Kotzbeck Pia Benedikt Thomas O. Eichmann Sohsuke Yamada Oskar Knittelfelder Clemens Diwoky Carina Doler Nicole Mayer Werner De Cecco Rolf Breinbauer Robert Zimmermann Rudolf Zechner
author_sort	Martina Schweiger
title	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
title_short	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
title_full	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
title_fullStr	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
title_full_unstemmed	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
title_sort	pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6897b936ca4b4463ba1c491fe09495d6
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Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

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