Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population
Abstract The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionall...
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Nature Portfolio
2018
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oai:doaj.org-article:6897fa65ccf04d51977aa36d485c63552021-12-02T15:08:35ZGender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population10.1038/s41598-017-18487-42045-2322https://doaj.org/article/6897fa65ccf04d51977aa36d485c63552018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-18487-4https://doaj.org/toc/2045-2322Abstract The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.Mariko SasakiSei HaradaYumiko KawasakiMiki WatanabeHidemi ItoHideo TanakaAyano TakeuchiKazuo TsubotaToru TakebayashiYuji NishiwakiRyo KawasakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
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Medicine R Science Q Mariko Sasaki Sei Harada Yumiko Kawasaki Miki Watanabe Hidemi Ito Hideo Tanaka Ayano Takeuchi Kazuo Tsubota Toru Takebayashi Yuji Nishiwaki Ryo Kawasaki Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| description |
Abstract The Tsuruoka Metabolomics Cohort Study included subjects aged 35–74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17–2.23 and 0.64–0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01–1.44 and 1.03–1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10–5.04) than men (OR: 1.65, 95% CI: 1.02–2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex. |
| format |
article |
| author |
Mariko Sasaki Sei Harada Yumiko Kawasaki Miki Watanabe Hidemi Ito Hideo Tanaka Ayano Takeuchi Kazuo Tsubota Toru Takebayashi Yuji Nishiwaki Ryo Kawasaki |
| author_facet |
Mariko Sasaki Sei Harada Yumiko Kawasaki Miki Watanabe Hidemi Ito Hideo Tanaka Ayano Takeuchi Kazuo Tsubota Toru Takebayashi Yuji Nishiwaki Ryo Kawasaki |
| author_sort |
Mariko Sasaki |
| title |
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| title_short |
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| title_full |
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| title_fullStr |
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| title_full_unstemmed |
Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population |
| title_sort |
gender-specific association of early age-related macular degeneration with systemic and genetic factors in a japanese population |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/6897fa65ccf04d51977aa36d485c6355 |
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1718388063460130816 |