Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults

Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown that diet–metabolic phenotype effect might be related to individual gut microbial profiles or enterotypes. Thus, the aim of this study was to examine whether microbial enter...

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Autores principales:	Jennifer N. Martinez-Medina, Regina Flores-Lopez, Blanca E. López-Contreras, Hugo Villamil-Ramirez, Daniela Guzman-Muñoz, Luis R. Macias-Kauffer, Paola León-Mimila, Omar Granados-Portillo, Blanca E. Del-Rio-Navarro, Francisco J. Gómez-Perez, Carlos A. Aguilar-Salinas, Nimbe Torres, Armando R. Tovar, Samuel Canizales-Quinteros, Sofia Moran-Ramos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dietary fiber hemicellulose insoluble fiber gut microbiota enterotypes school-age children Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/689a77fc838f4e6aaf06ae3576140ac9
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spelling	oai:doaj.org-article:689a77fc838f4e6aaf06ae3576140ac92021-11-25T18:35:01ZEffect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults10.3390/nu131138922072-6643https://doaj.org/article/689a77fc838f4e6aaf06ae3576140ac92021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3892https://doaj.org/toc/2072-6643Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown that diet–metabolic phenotype effect might be related to individual gut microbial profiles or enterotypes. Thus, the aim of this study was to examine whether microbial enterotypes modify the association between DF intake and metabolic traits. This cross-sectional study included 204 children (6–12 years old) and 75 adults (18–60 years old). Habitual DF intake was estimated with a Food Frequency Questionnaire and biochemical, clinical and anthropometric data were obtained. Gut microbiota was assessed through 16S sequencing and participants were stratified by enterotypes. Correlations adjusting for age and sex were performed to test the associations between dietary fiber components intake and metabolic traits. In children and adults from the <i>Prevotella</i> enterotype, a nominal negative correlation of hemicellulose intake with insulin and HOMA-IR levels was observed (<i>p</i> < 0.05), while in individuals of the other enterotypes, these associations were not observed. Interestingly, the latter effect was not related to the fecal short-chain-fatty acids profile. Our results contribute to understanding the enterotype influence on the diet–phenotype interaction, which ultimate could provide evidence for their use as potential biomarkers for future precision nutrition strategies.Jennifer N. Martinez-MedinaRegina Flores-LopezBlanca E. López-ContrerasHugo Villamil-RamirezDaniela Guzman-MuñozLuis R. Macias-KaufferPaola León-MimilaOmar Granados-PortilloBlanca E. Del-Rio-NavarroFrancisco J. Gómez-PerezCarlos A. Aguilar-SalinasNimbe TorresArmando R. TovarSamuel Canizales-QuinterosSofia Moran-RamosMDPI AGarticledietary fiberhemicelluloseinsoluble fibergut microbiotaenterotypesschool-age childrenNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3892, p 3892 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dietary fiber hemicellulose insoluble fiber gut microbiota enterotypes school-age children Nutrition. Foods and food supply TX341-641
spellingShingle	dietary fiber hemicellulose insoluble fiber gut microbiota enterotypes school-age children Nutrition. Foods and food supply TX341-641 Jennifer N. Martinez-Medina Regina Flores-Lopez Blanca E. López-Contreras Hugo Villamil-Ramirez Daniela Guzman-Muñoz Luis R. Macias-Kauffer Paola León-Mimila Omar Granados-Portillo Blanca E. Del-Rio-Navarro Francisco J. Gómez-Perez Carlos A. Aguilar-Salinas Nimbe Torres Armando R. Tovar Samuel Canizales-Quinteros Sofia Moran-Ramos Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
description	Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown that diet–metabolic phenotype effect might be related to individual gut microbial profiles or enterotypes. Thus, the aim of this study was to examine whether microbial enterotypes modify the association between DF intake and metabolic traits. This cross-sectional study included 204 children (6–12 years old) and 75 adults (18–60 years old). Habitual DF intake was estimated with a Food Frequency Questionnaire and biochemical, clinical and anthropometric data were obtained. Gut microbiota was assessed through 16S sequencing and participants were stratified by enterotypes. Correlations adjusting for age and sex were performed to test the associations between dietary fiber components intake and metabolic traits. In children and adults from the <i>Prevotella</i> enterotype, a nominal negative correlation of hemicellulose intake with insulin and HOMA-IR levels was observed (<i>p</i> < 0.05), while in individuals of the other enterotypes, these associations were not observed. Interestingly, the latter effect was not related to the fecal short-chain-fatty acids profile. Our results contribute to understanding the enterotype influence on the diet–phenotype interaction, which ultimate could provide evidence for their use as potential biomarkers for future precision nutrition strategies.
format	article
author	Jennifer N. Martinez-Medina Regina Flores-Lopez Blanca E. López-Contreras Hugo Villamil-Ramirez Daniela Guzman-Muñoz Luis R. Macias-Kauffer Paola León-Mimila Omar Granados-Portillo Blanca E. Del-Rio-Navarro Francisco J. Gómez-Perez Carlos A. Aguilar-Salinas Nimbe Torres Armando R. Tovar Samuel Canizales-Quinteros Sofia Moran-Ramos
author_facet	Jennifer N. Martinez-Medina Regina Flores-Lopez Blanca E. López-Contreras Hugo Villamil-Ramirez Daniela Guzman-Muñoz Luis R. Macias-Kauffer Paola León-Mimila Omar Granados-Portillo Blanca E. Del-Rio-Navarro Francisco J. Gómez-Perez Carlos A. Aguilar-Salinas Nimbe Torres Armando R. Tovar Samuel Canizales-Quinteros Sofia Moran-Ramos
author_sort	Jennifer N. Martinez-Medina
title	Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
title_short	Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
title_full	Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
title_fullStr	Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
title_full_unstemmed	Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults
title_sort	effect of gut microbial enterotypes on the association between habitual dietary fiber intake and insulin resistance markers in mexican children and adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/689a77fc838f4e6aaf06ae3576140ac9
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Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults

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