Germline genome modification through novel political, ethical, and social lenses.

Much has been written about gene modifying technologies (GMTs), with a particularly strong focus on human germline genome editing (HGGE) sparked by its unprecedented clinical research application in 2018, shocking the scientific community. This paper applies political, ethical, and social lenses to...

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Autores principales:	Vicki Xafis, G Owen Schaefer, Markus K Labude, Yujia Zhu, Soren Holm, Roger Sik-Yin Foo, Poh San Lai, Ruth Chadwick
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/689ad2eb3b564d6eb6551d5e7b25fb64
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spelling	oai:doaj.org-article:689ad2eb3b564d6eb6551d5e7b25fb642021-12-02T20:03:21ZGermline genome modification through novel political, ethical, and social lenses.1553-73901553-740410.1371/journal.pgen.1009741https://doaj.org/article/689ad2eb3b564d6eb6551d5e7b25fb642021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009741https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Much has been written about gene modifying technologies (GMTs), with a particularly strong focus on human germline genome editing (HGGE) sparked by its unprecedented clinical research application in 2018, shocking the scientific community. This paper applies political, ethical, and social lenses to aspects of HGGE to uncover previously underexplored considerations that are important to reflect on in global discussions. By exploring 4 areas-(1) just distribution of HGGE benefits through a realist lens; (2) HGGE through a national interest lens; (3) "broad societal consensus" through a structural injustice lens; and (4) HGGE through a scientific trustworthiness lens-a broader perspective is offered, which ultimately aims to enrich further debates and inform well-considered solutions for developments in this field. The application of these lenses also brings to light the fact that all discussions about scientific developments involve a conscious or unconscious application of a lens that shapes the direction of our thinking.Vicki XafisG Owen SchaeferMarkus K LabudeYujia ZhuSoren HolmRoger Sik-Yin FooPoh San LaiRuth ChadwickPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 9, p e1009741 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Vicki Xafis G Owen Schaefer Markus K Labude Yujia Zhu Soren Holm Roger Sik-Yin Foo Poh San Lai Ruth Chadwick Germline genome modification through novel political, ethical, and social lenses.
description	Much has been written about gene modifying technologies (GMTs), with a particularly strong focus on human germline genome editing (HGGE) sparked by its unprecedented clinical research application in 2018, shocking the scientific community. This paper applies political, ethical, and social lenses to aspects of HGGE to uncover previously underexplored considerations that are important to reflect on in global discussions. By exploring 4 areas-(1) just distribution of HGGE benefits through a realist lens; (2) HGGE through a national interest lens; (3) "broad societal consensus" through a structural injustice lens; and (4) HGGE through a scientific trustworthiness lens-a broader perspective is offered, which ultimately aims to enrich further debates and inform well-considered solutions for developments in this field. The application of these lenses also brings to light the fact that all discussions about scientific developments involve a conscious or unconscious application of a lens that shapes the direction of our thinking.
format	article
author	Vicki Xafis G Owen Schaefer Markus K Labude Yujia Zhu Soren Holm Roger Sik-Yin Foo Poh San Lai Ruth Chadwick
author_facet	Vicki Xafis G Owen Schaefer Markus K Labude Yujia Zhu Soren Holm Roger Sik-Yin Foo Poh San Lai Ruth Chadwick
author_sort	Vicki Xafis
title	Germline genome modification through novel political, ethical, and social lenses.
title_short	Germline genome modification through novel political, ethical, and social lenses.
title_full	Germline genome modification through novel political, ethical, and social lenses.
title_fullStr	Germline genome modification through novel political, ethical, and social lenses.
title_full_unstemmed	Germline genome modification through novel political, ethical, and social lenses.
title_sort	germline genome modification through novel political, ethical, and social lenses.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/689ad2eb3b564d6eb6551d5e7b25fb64
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Germline genome modification through novel political, ethical, and social lenses.

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