Genetics and age-related macular degeneration: a practical review for the clinician

Stephen G Schwartz,1 Blake M Hampton,1 Jaclyn L Kovach,1 Milam A Brantley Jr2 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashv...

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Autores principales:	Schwartz SG, Hampton BM, Kovach JL, Brantley MA Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Age-related macular degeneration (AMD) Age-related maculopathy susceptibility 2 (ARMS2) Complement factor H (CFH) Pharmacogenetics Vascular endothelial growth factor (VEGF) Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/689fb8172d434b14b9b5b632914f0200
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spelling	oai:doaj.org-article:689fb8172d434b14b9b5b632914f02002021-12-02T02:57:52ZGenetics and age-related macular degeneration: a practical review for the clinician1177-5483https://doaj.org/article/689fb8172d434b14b9b5b632914f02002016-07-01T00:00:00Zhttps://www.dovepress.com/genetics-and-age-related-macular-degeneration-a-practical-review-for-t-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Stephen G Schwartz,1 Blake M Hampton,1 Jaclyn L Kovach,1 Milam A Brantley Jr2 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA Abstract: Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients. Keywords: age-related macular degeneration, age-related maculopathy susceptibility 2, ARMS2, complement factor H, CFH, pharmacogenetics, vascular endothelial growth factorSchwartz SGHampton BMKovach JLBrantley MA JrDove Medical PressarticleAge-related macular degeneration (AMD)Age-related maculopathy susceptibility 2 (ARMS2)Complement factor H (CFH)PharmacogeneticsVascular endothelial growth factor (VEGF)OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 1229-1235 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Age-related macular degeneration (AMD) Age-related maculopathy susceptibility 2 (ARMS2) Complement factor H (CFH) Pharmacogenetics Vascular endothelial growth factor (VEGF) Ophthalmology RE1-994
spellingShingle	Age-related macular degeneration (AMD) Age-related maculopathy susceptibility 2 (ARMS2) Complement factor H (CFH) Pharmacogenetics Vascular endothelial growth factor (VEGF) Ophthalmology RE1-994 Schwartz SG Hampton BM Kovach JL Brantley MA Jr Genetics and age-related macular degeneration: a practical review for the clinician
description	Stephen G Schwartz,1 Blake M Hampton,1 Jaclyn L Kovach,1 Milam A Brantley Jr2 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN, USA Abstract: Age-related macular degeneration is a complex disease, with both genetic and environmental risk factors interacting in unknown ways. Currently, 52 gene variants within 34 loci have been significantly associated with age-related macular degeneration. Two well-studied major genes are complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2). There exist several commercially available tests that are proposed to stratify patients into high-risk and low-risk groups, as well as predict response to nutritional supplementation. However, at present, the bulk of the available peer-reviewed evidence suggests that genetic testing is more useful as a research tool than for clinical management of patients. Keywords: age-related macular degeneration, age-related maculopathy susceptibility 2, ARMS2, complement factor H, CFH, pharmacogenetics, vascular endothelial growth factor
format	article
author	Schwartz SG Hampton BM Kovach JL Brantley MA Jr
author_facet	Schwartz SG Hampton BM Kovach JL Brantley MA Jr
author_sort	Schwartz SG
title	Genetics and age-related macular degeneration: a practical review for the clinician
title_short	Genetics and age-related macular degeneration: a practical review for the clinician
title_full	Genetics and age-related macular degeneration: a practical review for the clinician
title_fullStr	Genetics and age-related macular degeneration: a practical review for the clinician
title_full_unstemmed	Genetics and age-related macular degeneration: a practical review for the clinician
title_sort	genetics and age-related macular degeneration: a practical review for the clinician
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/689fb8172d434b14b9b5b632914f0200
work_keys_str_mv	AT schwartzsg geneticsandagerelatedmaculardegenerationapracticalreviewfortheclinician AT hamptonbm geneticsandagerelatedmaculardegenerationapracticalreviewfortheclinician AT kovachjl geneticsandagerelatedmaculardegenerationapracticalreviewfortheclinician AT brantleymajr geneticsandagerelatedmaculardegenerationapracticalreviewfortheclinician
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Genetics and age-related macular degeneration: a practical review for the clinician

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