LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.

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Detalles Bibliográficos
Autores principales: Eun-Jin Bae, Dong-Kyu Kim, Changyoun Kim, Michael Mante, Anthony Adame, Edward Rockenstein, Ayse Ulusoy, Michael Klinkenberg, Ga Ram Jeong, Jae Ryul Bae, Cheolsoon Lee, He-Jin Lee, Byung-Dae Lee, Donato A. Di Monte, Eliezer Masliah, Seung-Jae Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/68a216617c8c47b59c9f66769ef9a5b0
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Descripción
Sumario:Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.

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