Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug potential and use it to identify a YAP:TEAD inhibitor.

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Autores principales:	Zachary R. Crook, Gregory P. Sevilla, Della Friend, Mi-Youn Brusniak, Ashok D. Bandaranayake, Midori Clarke, Mesfin Gewe, Andrew J. Mhyre, David Baker, Roland K. Strong, Philip Bradley, James M. Olson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68a2dc186894404db175693588126a0e
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spelling	oai:doaj.org-article:68a2dc186894404db175693588126a0e2021-12-02T14:41:18ZMammalian display screening of diverse cystine-dense peptides for difficult to drug targets10.1038/s41467-017-02098-82041-1723https://doaj.org/article/68a2dc186894404db175693588126a0e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02098-8https://doaj.org/toc/2041-1723Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug potential and use it to identify a YAP:TEAD inhibitor.Zachary R. CrookGregory P. SevillaDella FriendMi-Youn BrusniakAshok D. BandaranayakeMidori ClarkeMesfin GeweAndrew J. MhyreDavid BakerRoland K. StrongPhilip BradleyJames M. OlsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zachary R. Crook Gregory P. Sevilla Della Friend Mi-Youn Brusniak Ashok D. Bandaranayake Midori Clarke Mesfin Gewe Andrew J. Mhyre David Baker Roland K. Strong Philip Bradley James M. Olson Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
description	Pathologies related to protein:protein interaction are hard to treat but cystine-dense peptides have the potential to disrupt such interactions. Here the authors develop a high-diversity mammalian cell screen for cystine-dense peptides with drug potential and use it to identify a YAP:TEAD inhibitor.
format	article
author	Zachary R. Crook Gregory P. Sevilla Della Friend Mi-Youn Brusniak Ashok D. Bandaranayake Midori Clarke Mesfin Gewe Andrew J. Mhyre David Baker Roland K. Strong Philip Bradley James M. Olson
author_facet	Zachary R. Crook Gregory P. Sevilla Della Friend Mi-Youn Brusniak Ashok D. Bandaranayake Midori Clarke Mesfin Gewe Andrew J. Mhyre David Baker Roland K. Strong Philip Bradley James M. Olson
author_sort	Zachary R. Crook
title	Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
title_short	Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
title_full	Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
title_fullStr	Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
title_full_unstemmed	Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
title_sort	mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68a2dc186894404db175693588126a0e
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Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets

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