Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis

Abstract We investigated the prevalence of magnetic resonance imaging (MRI) findings and their relationship with knee symptoms in women without radiographic evidence of knee osteoarthritis (KOA). This cross-sectional cohort study included 359 Japanese women without radiographic evidence of KOA (Kell...

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Autores principales:	Seiya Ota, Eiji Sasaki, Shizuka Sasaki, Daisuke Chiba, Yuka Kimura, Yuji Yamamoto, Mika Kumagai, Masataka Ando, Eiichi Tsuda, Yasuyuki Ishibashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68a5374822e64728952342e8689fab39
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spelling	oai:doaj.org-article:68a5374822e64728952342e8689fab392021-12-02T16:24:22ZRelationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis10.1038/s41598-021-94382-32045-2322https://doaj.org/article/68a5374822e64728952342e8689fab392021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94382-3https://doaj.org/toc/2045-2322Abstract We investigated the prevalence of magnetic resonance imaging (MRI) findings and their relationship with knee symptoms in women without radiographic evidence of knee osteoarthritis (KOA). This cross-sectional cohort study included 359 Japanese women without radiographic evidence of KOA (Kellgren‒Lawrence grade < 2). All participants underwent T2-weighted fat-suppressed MRI of their knees. Structural abnormalities (cartilage damage, bone marrow lesions [BMLs], subchondral cysts, bone attrition, osteophytes, meniscal lesions, and synovitis) were scored according to the whole-organ MRI score method. Knee symptoms were evaluated using the Knee Injury and Osteoarthritis Outcome Score. Participants were divided into early and non-KOA groups based on early KOA classification criteria. Logistic regression analysis was performed to evaluate the relationship between MRI abnormalities and knee symptoms. Cartilage damage was the most common abnormality (43.5%). The prevalences of cartilage damage, BMLs, subchondral cysts, bone attrition, meniscal lesions, and synovitis were higher in patients with early KOA than in those without. Synovitis (odds ratio [OR] 2.254, P = 0.002) and meniscal lesions (OR 1.479, P = 0.031) were positively associated with the presence of early KOA. Synovitis was most strongly associated with knee pain and might be a therapeutic target in patients with early KOA.Seiya OtaEiji SasakiShizuka SasakiDaisuke ChibaYuka KimuraYuji YamamotoMika KumagaiMasataka AndoEiichi TsudaYasuyuki IshibashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seiya Ota Eiji Sasaki Shizuka Sasaki Daisuke Chiba Yuka Kimura Yuji Yamamoto Mika Kumagai Masataka Ando Eiichi Tsuda Yasuyuki Ishibashi Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
description	Abstract We investigated the prevalence of magnetic resonance imaging (MRI) findings and their relationship with knee symptoms in women without radiographic evidence of knee osteoarthritis (KOA). This cross-sectional cohort study included 359 Japanese women without radiographic evidence of KOA (Kellgren‒Lawrence grade < 2). All participants underwent T2-weighted fat-suppressed MRI of their knees. Structural abnormalities (cartilage damage, bone marrow lesions [BMLs], subchondral cysts, bone attrition, osteophytes, meniscal lesions, and synovitis) were scored according to the whole-organ MRI score method. Knee symptoms were evaluated using the Knee Injury and Osteoarthritis Outcome Score. Participants were divided into early and non-KOA groups based on early KOA classification criteria. Logistic regression analysis was performed to evaluate the relationship between MRI abnormalities and knee symptoms. Cartilage damage was the most common abnormality (43.5%). The prevalences of cartilage damage, BMLs, subchondral cysts, bone attrition, meniscal lesions, and synovitis were higher in patients with early KOA than in those without. Synovitis (odds ratio [OR] 2.254, P = 0.002) and meniscal lesions (OR 1.479, P = 0.031) were positively associated with the presence of early KOA. Synovitis was most strongly associated with knee pain and might be a therapeutic target in patients with early KOA.
format	article
author	Seiya Ota Eiji Sasaki Shizuka Sasaki Daisuke Chiba Yuka Kimura Yuji Yamamoto Mika Kumagai Masataka Ando Eiichi Tsuda Yasuyuki Ishibashi
author_facet	Seiya Ota Eiji Sasaki Shizuka Sasaki Daisuke Chiba Yuka Kimura Yuji Yamamoto Mika Kumagai Masataka Ando Eiichi Tsuda Yasuyuki Ishibashi
author_sort	Seiya Ota
title	Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
title_short	Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
title_full	Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
title_fullStr	Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
title_full_unstemmed	Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
title_sort	relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/68a5374822e64728952342e8689fab39
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Relationship between abnormalities detected by magnetic resonance imaging and knee symptoms in early knee osteoarthritis

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