Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults

Einas S Al-Eisa,1 Ahmad H Alghadir,1 Sami A Gabr1,2 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt Purpose: The purpose of this study was t...

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Autores principales:	Al-Eisa ES, Alghadir AH, Gabr SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Physical activity Muscle fatigue Total antioxidant capacity 25-(OH) D concentrations Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/68a6fe2fa38e4c1ba815a6d5345ef90a
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spelling	oai:doaj.org-article:68a6fe2fa38e4c1ba815a6d5345ef90a2021-12-02T05:17:59ZCorrelation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults1178-1998https://doaj.org/article/68a6fe2fa38e4c1ba815a6d5345ef90a2016-05-01T00:00:00Zhttps://www.dovepress.com/correlation-between-vitamin-d-levels-and-muscle-fatigue-risk-factors-b-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Einas S Al-Eisa,1 Ahmad H Alghadir,1 Sami A Gabr1,2 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt Purpose: The purpose of this study was to investigate the relationship of serum vitamin D levels with physical activity, obesity, muscle fatigue biomarkers, and total antioxidant capacity (TAC) in healthy older adults.Methods: A total of 85 healthy older subjects aged 64–96 years were recruited in this study. Based on estimated energy expenditure scores, the participants were classified into three groups: inactive (n=25), moderate (n=20), and physically active (n=35). Serum 25(OH)D (25-hydroxy vitamin D) levels, metabolic syndrome parameters, TAC activity, muscle fatigue biomarkers (Ca, creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline), physical activity, body fatness, and fatigue score (visual analog scale) were estimated using immunoassay techniques and prevalidated questionnaires, respectively.Results: Physical activity was estimated in 64.6% of the participants. Males showed higher physical activity (42.5%) compared to females (26.25%). Compared to participants with lower activity, significant reduction in body mass index, waist circumference, hips, fasting blood sugar, triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol were observed in moderate and physically active participants. Also, significant increase in the levels of serum 25(OH)D concentrations, calcium, and TAC activity along with reduction in the levels of muscle fatigue biomarkers: creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline, and fatigue scores (visual analog scale) were reported in physically active participants compared to those of lower physical activity. In all participants, serum 25(OH)D concentrations correlated positively with Ca, TAC, physical activity scores, and negatively with body mass index, lipid profile, fatigue scores (visual analog scale), and muscle fatigue biomarkers. Stepwise regression analysis showed that serum 25(OH)D concentrations, physical activity, Ca, TAC, and demographic parameters explained approximately 61.4%–85.8% of reduction in both fatigue scores and muscle fatigue biomarkers with substantial improvement in muscle performance in healthy older adults.Conclusion: The data showed that considerable levels of 25(OH)D concentrations, calcium intake, and lower obesity positively correlated with the improvement in the muscle relief and performance of physically active participants. These results demonstrate that 25(OH)D concentrations and calcium might prevent muscle fatigue by regulation of the biosynthesis of creatine kinase, lactic acid dehydrogenase, troponin I, and hydroxyproline via a proposed antifree radical mechanism reported by higher TAC activity. It was suggested that vitamin D status could be reported as a marker of the improvement of muscle performance, especially in healthy older adults with lower physical activity. Keywords: exercise, physical fitness, muscle stress, oxidative stress, 25(OH)D concentrations, troponin I, hydroxyprolineA Letter to the Editor has been received and published for this article. Al-Eisa ESAlghadir AHGabr SADove Medical PressarticlePhysical activityMuscle fatigueTotal antioxidant capacity25-(OH) D concentrationsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 513-522 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physical activity Muscle fatigue Total antioxidant capacity 25-(OH) D concentrations Geriatrics RC952-954.6
spellingShingle	Physical activity Muscle fatigue Total antioxidant capacity 25-(OH) D concentrations Geriatrics RC952-954.6 Al-Eisa ES Alghadir AH Gabr SA Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
description	Einas S Al-Eisa,1 Ahmad H Alghadir,1 Sami A Gabr1,2 1Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia; 2Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt Purpose: The purpose of this study was to investigate the relationship of serum vitamin D levels with physical activity, obesity, muscle fatigue biomarkers, and total antioxidant capacity (TAC) in healthy older adults.Methods: A total of 85 healthy older subjects aged 64–96 years were recruited in this study. Based on estimated energy expenditure scores, the participants were classified into three groups: inactive (n=25), moderate (n=20), and physically active (n=35). Serum 25(OH)D (25-hydroxy vitamin D) levels, metabolic syndrome parameters, TAC activity, muscle fatigue biomarkers (Ca, creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline), physical activity, body fatness, and fatigue score (visual analog scale) were estimated using immunoassay techniques and prevalidated questionnaires, respectively.Results: Physical activity was estimated in 64.6% of the participants. Males showed higher physical activity (42.5%) compared to females (26.25%). Compared to participants with lower activity, significant reduction in body mass index, waist circumference, hips, fasting blood sugar, triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol were observed in moderate and physically active participants. Also, significant increase in the levels of serum 25(OH)D concentrations, calcium, and TAC activity along with reduction in the levels of muscle fatigue biomarkers: creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline, and fatigue scores (visual analog scale) were reported in physically active participants compared to those of lower physical activity. In all participants, serum 25(OH)D concentrations correlated positively with Ca, TAC, physical activity scores, and negatively with body mass index, lipid profile, fatigue scores (visual analog scale), and muscle fatigue biomarkers. Stepwise regression analysis showed that serum 25(OH)D concentrations, physical activity, Ca, TAC, and demographic parameters explained approximately 61.4%–85.8% of reduction in both fatigue scores and muscle fatigue biomarkers with substantial improvement in muscle performance in healthy older adults.Conclusion: The data showed that considerable levels of 25(OH)D concentrations, calcium intake, and lower obesity positively correlated with the improvement in the muscle relief and performance of physically active participants. These results demonstrate that 25(OH)D concentrations and calcium might prevent muscle fatigue by regulation of the biosynthesis of creatine kinase, lactic acid dehydrogenase, troponin I, and hydroxyproline via a proposed antifree radical mechanism reported by higher TAC activity. It was suggested that vitamin D status could be reported as a marker of the improvement of muscle performance, especially in healthy older adults with lower physical activity. Keywords: exercise, physical fitness, muscle stress, oxidative stress, 25(OH)D concentrations, troponin I, hydroxyprolineA Letter to the Editor has been received and published for this article.
format	article
author	Al-Eisa ES Alghadir AH Gabr SA
author_facet	Al-Eisa ES Alghadir AH Gabr SA
author_sort	Al-Eisa ES
title	Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
title_short	Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
title_full	Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
title_fullStr	Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
title_full_unstemmed	Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults
title_sort	correlation between vitamin d levels and muscle fatigue risk factors based on physical activity in healthy older adults
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/68a6fe2fa38e4c1ba815a6d5345ef90a
work_keys_str_mv	AT aleisaes correlationbetweenvitamindlevelsandmusclefatigueriskfactorsbasedonphysicalactivityinhealthyolderadults AT alghadirah correlationbetweenvitamindlevelsandmusclefatigueriskfactorsbasedonphysicalactivityinhealthyolderadults AT gabrsa correlationbetweenvitamindlevelsandmusclefatigueriskfactorsbasedonphysicalactivityinhealthyolderadults
_version_	1718400475672346624

Correlation between vitamin D levels and muscle fatigue risk factors based on physical activity in healthy older adults

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