A two-microRNA signature predicts the progression of male thyroid cancer

In various cancers, microRNAs (miRNAs) are abnormally expressed, including thyroid cancer (TC). In recent years, the incidence of TC has increased annually around the world. Compared with female patients, male TC patients are more likely to have a postoperative recurrence and lymph node metastasis,...

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Autores principales:	Liu Bingyang, Shi Haihong, Qiu Weigang, Wu Xinquan, Li Liqiong, Wu Wenyi
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	male thyroid cancer microrna signature tumour progression mir-451a mir-16-1-3p Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/68a76a11c3344b80a1eaf7a36400d232
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spelling	oai:doaj.org-article:68a76a11c3344b80a1eaf7a36400d2322021-12-05T14:10:41ZA two-microRNA signature predicts the progression of male thyroid cancer2391-541210.1515/biol-2021-0099https://doaj.org/article/68a76a11c3344b80a1eaf7a36400d2322021-09-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0099https://doaj.org/toc/2391-5412In various cancers, microRNAs (miRNAs) are abnormally expressed, including thyroid cancer (TC). In recent years, the incidence of TC has increased annually around the world. Compared with female patients, male TC patients are more likely to have a postoperative recurrence and lymph node metastasis, and hence need second treatments. However, the molecular biological processes underlying this phenomenon are not understood. Therefore, we collected data on miRNA expression and clinical information of male TC patients from The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs were identified between male TC tissues and matched normal tissues. The Kaplan–Meier method, univariate and multivariate Cox regressions, and receiver operating characteristic curve analyses were performed to assess the association between miRNAs and the disease-free survival of male TC patients. Gene Ontology (GO) and the Kyoto Encyclopaedia of Gene and Genome (KEGG) enrichment analyses were then used to explore the function of miRNA target genes. Furthermore, we evaluated the ability of the miRNA biomarker to predict survival in female TC patients. As a result, a total of 118 differentially expressed miRNAs were identified, including 25 upregulated and 93 downregulated miRNAs. Among them, miR-451a and miR-16-1-3p were confirmed to be independent prognostic factors for the disease-free survival rate. The target genes of miR-451a and miR-16-1-3p were identified, and functional analysis showed that these genes were enriched in 25 Go and KEGG accessions, including cell signal transduction, motor adhesion, phagocytosis, regulation of transcription, cell proliferation, angiogenesis, etc. Neither miR-451a and miR-16-1-3p, nor a prediction model based on both miRNAs effectively predicted survival in female TC patients. In conclusion, both miR-451a and miR-16-1-3p may play important roles in the processes of male TC. The two-miRNA signature involving miR-1258 and miR-193a may serve as a novel prognostic biomarker for male TC patients.Liu BingyangShi HaihongQiu WeigangWu XinquanLi LiqiongWu WenyiDe Gruyterarticlemale thyroid cancermicrorna signaturetumour progressionmir-451amir-16-1-3pBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 981-991 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	male thyroid cancer microrna signature tumour progression mir-451a mir-16-1-3p Biology (General) QH301-705.5
spellingShingle	male thyroid cancer microrna signature tumour progression mir-451a mir-16-1-3p Biology (General) QH301-705.5 Liu Bingyang Shi Haihong Qiu Weigang Wu Xinquan Li Liqiong Wu Wenyi A two-microRNA signature predicts the progression of male thyroid cancer
description	In various cancers, microRNAs (miRNAs) are abnormally expressed, including thyroid cancer (TC). In recent years, the incidence of TC has increased annually around the world. Compared with female patients, male TC patients are more likely to have a postoperative recurrence and lymph node metastasis, and hence need second treatments. However, the molecular biological processes underlying this phenomenon are not understood. Therefore, we collected data on miRNA expression and clinical information of male TC patients from The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs were identified between male TC tissues and matched normal tissues. The Kaplan–Meier method, univariate and multivariate Cox regressions, and receiver operating characteristic curve analyses were performed to assess the association between miRNAs and the disease-free survival of male TC patients. Gene Ontology (GO) and the Kyoto Encyclopaedia of Gene and Genome (KEGG) enrichment analyses were then used to explore the function of miRNA target genes. Furthermore, we evaluated the ability of the miRNA biomarker to predict survival in female TC patients. As a result, a total of 118 differentially expressed miRNAs were identified, including 25 upregulated and 93 downregulated miRNAs. Among them, miR-451a and miR-16-1-3p were confirmed to be independent prognostic factors for the disease-free survival rate. The target genes of miR-451a and miR-16-1-3p were identified, and functional analysis showed that these genes were enriched in 25 Go and KEGG accessions, including cell signal transduction, motor adhesion, phagocytosis, regulation of transcription, cell proliferation, angiogenesis, etc. Neither miR-451a and miR-16-1-3p, nor a prediction model based on both miRNAs effectively predicted survival in female TC patients. In conclusion, both miR-451a and miR-16-1-3p may play important roles in the processes of male TC. The two-miRNA signature involving miR-1258 and miR-193a may serve as a novel prognostic biomarker for male TC patients.
format	article
author	Liu Bingyang Shi Haihong Qiu Weigang Wu Xinquan Li Liqiong Wu Wenyi
author_facet	Liu Bingyang Shi Haihong Qiu Weigang Wu Xinquan Li Liqiong Wu Wenyi
author_sort	Liu Bingyang
title	A two-microRNA signature predicts the progression of male thyroid cancer
title_short	A two-microRNA signature predicts the progression of male thyroid cancer
title_full	A two-microRNA signature predicts the progression of male thyroid cancer
title_fullStr	A two-microRNA signature predicts the progression of male thyroid cancer
title_full_unstemmed	A two-microRNA signature predicts the progression of male thyroid cancer
title_sort	two-microrna signature predicts the progression of male thyroid cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/68a76a11c3344b80a1eaf7a36400d232
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A two-microRNA signature predicts the progression of male thyroid cancer

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