Structural and functional analysis of the human POT1-TPP1 telomeric complex

POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact its assembly and function.

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Autores principales:	Cory Rice, Prashanth Krishna Shastrula, Andrew V. Kossenkov, Robert Hills, Duncan M. Baird, Louise C. Showe, Tzanko Doukov, Susan Janicki, Emmanuel Skordalakes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68a7e5604c6d4e68a53198a88c48aee9
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spelling	oai:doaj.org-article:68a7e5604c6d4e68a53198a88c48aee92021-12-02T14:40:22ZStructural and functional analysis of the human POT1-TPP1 telomeric complex10.1038/ncomms149282041-1723https://doaj.org/article/68a7e5604c6d4e68a53198a88c48aee92017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14928https://doaj.org/toc/2041-1723POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact its assembly and function.Cory RicePrashanth Krishna ShastrulaAndrew V. KossenkovRobert HillsDuncan M. BairdLouise C. ShoweTzanko DoukovSusan JanickiEmmanuel SkordalakesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cory Rice Prashanth Krishna Shastrula Andrew V. Kossenkov Robert Hills Duncan M. Baird Louise C. Showe Tzanko Doukov Susan Janicki Emmanuel Skordalakes Structural and functional analysis of the human POT1-TPP1 telomeric complex
description	POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact its assembly and function.
format	article
author	Cory Rice Prashanth Krishna Shastrula Andrew V. Kossenkov Robert Hills Duncan M. Baird Louise C. Showe Tzanko Doukov Susan Janicki Emmanuel Skordalakes
author_facet	Cory Rice Prashanth Krishna Shastrula Andrew V. Kossenkov Robert Hills Duncan M. Baird Louise C. Showe Tzanko Doukov Susan Janicki Emmanuel Skordalakes
author_sort	Cory Rice
title	Structural and functional analysis of the human POT1-TPP1 telomeric complex
title_short	Structural and functional analysis of the human POT1-TPP1 telomeric complex
title_full	Structural and functional analysis of the human POT1-TPP1 telomeric complex
title_fullStr	Structural and functional analysis of the human POT1-TPP1 telomeric complex
title_full_unstemmed	Structural and functional analysis of the human POT1-TPP1 telomeric complex
title_sort	structural and functional analysis of the human pot1-tpp1 telomeric complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68a7e5604c6d4e68a53198a88c48aee9
work_keys_str_mv	AT coryrice structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT prashanthkrishnashastrula structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT andrewvkossenkov structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT roberthills structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT duncanmbaird structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT louisecshowe structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT tzankodoukov structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT susanjanicki structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex AT emmanuelskordalakes structuralandfunctionalanalysisofthehumanpot1tpp1telomericcomplex
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Structural and functional analysis of the human POT1-TPP1 telomeric complex

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