Active thrombin produced by the intestinal epithelium controls mucosal biofilms

Active thrombin produced by the intestinal epithelium controls mucosal biofilms

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

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Auteurs principaux: Jean-Paul Motta, Alexandre Denadai-Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Seguy, Noa Mathurine-Thomas, Heather J. Galipeau, Delphine Bonnet, Laurent Alric, Andre G. Buret, John L. Wallace, Antoine Dufour, Elena F. Verdu, Morley D. Hollenberg, Eric Oswald, Matteo Serino, Celine Deraison, Nathalie Vergnolle
Format: article
Langue:EN
Publié: Nature Portfolio 2019
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/68a8589ee36440b4a7b451d28d77ced9
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Résumé:The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

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