Active thrombin produced by the intestinal epithelium controls mucosal biofilms

The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.

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Autores principales:	Jean-Paul Motta, Alexandre Denadai-Souza, David Sagnat, Laura Guiraud, Anissa Edir, Chrystelle Bonnart, Mireille Sebbag, Perrine Rousset, Ariane Lapeyre, Carine Seguy, Noa Mathurine-Thomas, Heather J. Galipeau, Delphine Bonnet, Laurent Alric, Andre G. Buret, John L. Wallace, Antoine Dufour, Elena F. Verdu, Morley D. Hollenberg, Eric Oswald, Matteo Serino, Celine Deraison, Nathalie Vergnolle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68a8589ee36440b4a7b451d28d77ced9
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spelling	oai:doaj.org-article:68a8589ee36440b4a7b451d28d77ced92021-12-02T16:58:25ZActive thrombin produced by the intestinal epithelium controls mucosal biofilms10.1038/s41467-019-11140-w2041-1723https://doaj.org/article/68a8589ee36440b4a7b451d28d77ced92019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11140-whttps://doaj.org/toc/2041-1723The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.Jean-Paul MottaAlexandre Denadai-SouzaDavid SagnatLaura GuiraudAnissa EdirChrystelle BonnartMireille SebbagPerrine RoussetAriane LapeyreCarine SeguyNoa Mathurine-ThomasHeather J. GalipeauDelphine BonnetLaurent AlricAndre G. BuretJohn L. WallaceAntoine DufourElena F. VerduMorley D. HollenbergEric OswaldMatteo SerinoCeline DeraisonNathalie VergnolleNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jean-Paul Motta Alexandre Denadai-Souza David Sagnat Laura Guiraud Anissa Edir Chrystelle Bonnart Mireille Sebbag Perrine Rousset Ariane Lapeyre Carine Seguy Noa Mathurine-Thomas Heather J. Galipeau Delphine Bonnet Laurent Alric Andre G. Buret John L. Wallace Antoine Dufour Elena F. Verdu Morley D. Hollenberg Eric Oswald Matteo Serino Celine Deraison Nathalie Vergnolle Active thrombin produced by the intestinal epithelium controls mucosal biofilms
description	The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.
format	article
author	Jean-Paul Motta Alexandre Denadai-Souza David Sagnat Laura Guiraud Anissa Edir Chrystelle Bonnart Mireille Sebbag Perrine Rousset Ariane Lapeyre Carine Seguy Noa Mathurine-Thomas Heather J. Galipeau Delphine Bonnet Laurent Alric Andre G. Buret John L. Wallace Antoine Dufour Elena F. Verdu Morley D. Hollenberg Eric Oswald Matteo Serino Celine Deraison Nathalie Vergnolle
author_facet	Jean-Paul Motta Alexandre Denadai-Souza David Sagnat Laura Guiraud Anissa Edir Chrystelle Bonnart Mireille Sebbag Perrine Rousset Ariane Lapeyre Carine Seguy Noa Mathurine-Thomas Heather J. Galipeau Delphine Bonnet Laurent Alric Andre G. Buret John L. Wallace Antoine Dufour Elena F. Verdu Morley D. Hollenberg Eric Oswald Matteo Serino Celine Deraison Nathalie Vergnolle
author_sort	Jean-Paul Motta
title	Active thrombin produced by the intestinal epithelium controls mucosal biofilms
title_short	Active thrombin produced by the intestinal epithelium controls mucosal biofilms
title_full	Active thrombin produced by the intestinal epithelium controls mucosal biofilms
title_fullStr	Active thrombin produced by the intestinal epithelium controls mucosal biofilms
title_full_unstemmed	Active thrombin produced by the intestinal epithelium controls mucosal biofilms
title_sort	active thrombin produced by the intestinal epithelium controls mucosal biofilms
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/68a8589ee36440b4a7b451d28d77ced9
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Active thrombin produced by the intestinal epithelium controls mucosal biofilms

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