The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages

The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages

The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidati...

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Autores principales: Daejin Lim, Kwang Soo Kim, Jae-Ho Jeong, Oriana Marques, Hyun-Ju kim, Miryoung Song, Tae-Hoon Lee, Jae Il Kim, Hueng-Sik Choi, Jung-Joon Min, Dirk Bumann, Martina U. Muckenthaler, Hyon E. Choy
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/68a93fbb5483477d97468789d3299179
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spelling oai:doaj.org-article:68a93fbb5483477d97468789d32991792021-12-02T14:40:43ZThe hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages10.1038/s41467-018-04446-82041-1723https://doaj.org/article/68a93fbb5483477d97468789d32991792018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04446-8https://doaj.org/toc/2041-1723The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidative burst.Daejin LimKwang Soo KimJae-Ho JeongOriana MarquesHyun-Ju kimMiryoung SongTae-Hoon LeeJae Il KimHueng-Sik ChoiJung-Joon MinDirk BumannMartina U. MuckenthalerHyon E. ChoyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Daejin Lim
Kwang Soo Kim
Jae-Ho Jeong
Oriana Marques
Hyun-Ju kim
Miryoung Song
Tae-Hoon Lee
Jae Il Kim
Hueng-Sik Choi
Jung-Joon Min
Dirk Bumann
Martina U. Muckenthaler
Hyon E. Choy
The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
description The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidative burst.
format article
author Daejin Lim
Kwang Soo Kim
Jae-Ho Jeong
Oriana Marques
Hyun-Ju kim
Miryoung Song
Tae-Hoon Lee
Jae Il Kim
Hueng-Sik Choi
Jung-Joon Min
Dirk Bumann
Martina U. Muckenthaler
Hyon E. Choy
author_facet Daejin Lim
Kwang Soo Kim
Jae-Ho Jeong
Oriana Marques
Hyun-Ju kim
Miryoung Song
Tae-Hoon Lee
Jae Il Kim
Hueng-Sik Choi
Jung-Joon Min
Dirk Bumann
Martina U. Muckenthaler
Hyon E. Choy
author_sort Daejin Lim
title The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
title_short The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
title_full The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
title_fullStr The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
title_full_unstemmed The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages
title_sort hepcidin-ferroportin axis controls the iron content of salmonella-containing vacuoles in macrophages
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/68a93fbb5483477d97468789d3299179
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