Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

β1 and β2 adrenergic receptors (ARs) are the predominant G protein-coupled receptor subtypes expressed in mammalian hearts. Here the authors describe a signaling mechanism where the biased agonist carvedilol converts β1AR from a classical Gαs-coupled to a Gαi-coupled receptor to mediate β-arrestin-d...

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Autores principales:	Jialu Wang, Kenji Hanada, Dean P. Staus, Michael A. Makara, Giri Raj Dahal, Qiang Chen, Andrea Ahles, Stefan Engelhardt, Howard A. Rockman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68ae6a57361e4d6dbe16011c3ee3cc38
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spelling	oai:doaj.org-article:68ae6a57361e4d6dbe16011c3ee3cc382021-12-02T15:36:59ZGαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling10.1038/s41467-017-01855-z2041-1723https://doaj.org/article/68ae6a57361e4d6dbe16011c3ee3cc382017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01855-zhttps://doaj.org/toc/2041-1723β1 and β2 adrenergic receptors (ARs) are the predominant G protein-coupled receptor subtypes expressed in mammalian hearts. Here the authors describe a signaling mechanism where the biased agonist carvedilol converts β1AR from a classical Gαs-coupled to a Gαi-coupled receptor to mediate β-arrestin-dependent signaling.Jialu WangKenji HanadaDean P. StausMichael A. MakaraGiri Raj DahalQiang ChenAndrea AhlesStefan EngelhardtHoward A. RockmanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jialu Wang Kenji Hanada Dean P. Staus Michael A. Makara Giri Raj Dahal Qiang Chen Andrea Ahles Stefan Engelhardt Howard A. Rockman Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
description	β1 and β2 adrenergic receptors (ARs) are the predominant G protein-coupled receptor subtypes expressed in mammalian hearts. Here the authors describe a signaling mechanism where the biased agonist carvedilol converts β1AR from a classical Gαs-coupled to a Gαi-coupled receptor to mediate β-arrestin-dependent signaling.
format	article
author	Jialu Wang Kenji Hanada Dean P. Staus Michael A. Makara Giri Raj Dahal Qiang Chen Andrea Ahles Stefan Engelhardt Howard A. Rockman
author_facet	Jialu Wang Kenji Hanada Dean P. Staus Michael A. Makara Giri Raj Dahal Qiang Chen Andrea Ahles Stefan Engelhardt Howard A. Rockman
author_sort	Jialu Wang
title	Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
title_short	Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
title_full	Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
title_fullStr	Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
title_full_unstemmed	Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
title_sort	gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68ae6a57361e4d6dbe16011c3ee3cc38
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Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

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