Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment

Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment

Off-target mutations that occur at a frequency below 0.5% can be difficult to detect. Here the authors use predicted off-target amplification to increase detection sensitivity.

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Detalles Bibliográficos
Autores principales: Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An, Jong-Hee Lee, Young-Hyun Kim, Hanseop Kim, Yeounsun Oh, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Junho K. Hur, Sun-Uk Kim, Seung Hwan Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/68aec577321b412993220ff58b4f8fc4
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