JunB is essential for IL-23-dependent pathogenicity of Th17 cells

JunB is essential for IL-23-dependent pathogenicity of Th17 cells

T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.

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Autores principales: Zafrul Hasan, Shin-ichi Koizumi, Daiki Sasaki, Hayato Yamada, Nana Arakaki, Yoshitaka Fujihara, Shiho Okitsu, Hiroki Shirahata, Hiroki Ishikawa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/68b10b31b4c2404e89ca812ba7589cc1
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spelling oai:doaj.org-article:68b10b31b4c2404e89ca812ba7589cc12021-12-02T17:06:02ZJunB is essential for IL-23-dependent pathogenicity of Th17 cells10.1038/ncomms156282041-1723https://doaj.org/article/68b10b31b4c2404e89ca812ba7589cc12017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15628https://doaj.org/toc/2041-1723T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.Zafrul HasanShin-ichi KoizumiDaiki SasakiHayato YamadaNana ArakakiYoshitaka FujiharaShiho OkitsuHiroki ShirahataHiroki IshikawaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zafrul Hasan
Shin-ichi Koizumi
Daiki Sasaki
Hayato Yamada
Nana Arakaki
Yoshitaka Fujihara
Shiho Okitsu
Hiroki Shirahata
Hiroki Ishikawa
JunB is essential for IL-23-dependent pathogenicity of Th17 cells
description T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.
format article
author Zafrul Hasan
Shin-ichi Koizumi
Daiki Sasaki
Hayato Yamada
Nana Arakaki
Yoshitaka Fujihara
Shiho Okitsu
Hiroki Shirahata
Hiroki Ishikawa
author_facet Zafrul Hasan
Shin-ichi Koizumi
Daiki Sasaki
Hayato Yamada
Nana Arakaki
Yoshitaka Fujihara
Shiho Okitsu
Hiroki Shirahata
Hiroki Ishikawa
author_sort Zafrul Hasan
title JunB is essential for IL-23-dependent pathogenicity of Th17 cells
title_short JunB is essential for IL-23-dependent pathogenicity of Th17 cells
title_full JunB is essential for IL-23-dependent pathogenicity of Th17 cells
title_fullStr JunB is essential for IL-23-dependent pathogenicity of Th17 cells
title_full_unstemmed JunB is essential for IL-23-dependent pathogenicity of Th17 cells
title_sort junb is essential for il-23-dependent pathogenicity of th17 cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/68b10b31b4c2404e89ca812ba7589cc1
work_keys_str_mv AT zafrulhasan junbisessentialforil23dependentpathogenicityofth17cells
AT shinichikoizumi junbisessentialforil23dependentpathogenicityofth17cells
AT daikisasaki junbisessentialforil23dependentpathogenicityofth17cells
AT hayatoyamada junbisessentialforil23dependentpathogenicityofth17cells
AT nanaarakaki junbisessentialforil23dependentpathogenicityofth17cells
AT yoshitakafujihara junbisessentialforil23dependentpathogenicityofth17cells
AT shihookitsu junbisessentialforil23dependentpathogenicityofth17cells
AT hirokishirahata junbisessentialforil23dependentpathogenicityofth17cells
AT hirokiishikawa junbisessentialforil23dependentpathogenicityofth17cells
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