Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study

Abstract This study aimed to investigate the association of nonalcoholic fatty liver disease (NAFLD) and its severity with the decline in kidney function in patients with chronic kidney disease (CKD). We conducted a cohort study of 1,525 CKD patients who underwent repeated health check-up examinatio...

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Autores principales:	Hye Ryoun Jang, Danbee Kang, Dong Hyun Sinn, Seonhye Gu, Soo Jin Cho, Jung Eun Lee, Wooseong Huh, Seung Woon Paik, Seungho Ryu, Yoosoo Chang, Tariq Shafi, Mariana Lazo, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68b43c84612d46d6b74627428f2af9a9
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spelling	oai:doaj.org-article:68b43c84612d46d6b74627428f2af9a92021-12-02T15:08:24ZNonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study10.1038/s41598-018-23014-02045-2322https://doaj.org/article/68b43c84612d46d6b74627428f2af9a92018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23014-0https://doaj.org/toc/2045-2322Abstract This study aimed to investigate the association of nonalcoholic fatty liver disease (NAFLD) and its severity with the decline in kidney function in patients with chronic kidney disease (CKD). We conducted a cohort study of 1,525 CKD patients who underwent repeated health check-up examinations from January 2003 through December 2013. NAFLD was diagnosed by ultrasonography and its severity was assessed by the NAFLD fibrosis score. At baseline, the prevalence of NAFLD was 40.9%, and the mean estimated glomerular filtration rate (eGFR) was 59.1 ml/min/1.73 m2. The average follow-up was 6.5 years. The age- and sex-adjusted decline in eGFR was greater in patients with NAFLD (−0.79% per year, 95% CI −1.31%, −0.27%) compared to those without it (0.30%, 95% CI −0.14%, 0.76%; p = 0.002). In multivariable adjusted models, the average difference in annual percent change in decline in eGFR comparing patients with NAFLD to those without NAFLD was −1.06% (−1.73%, −0.38%; p = 0.002). The decline in eGFR associated with NAFLD was greater in patients with higher NAFLD fibrosis score, in those with proteinuria or with low eGFR at baseline ( <45 ml/min/1.73 m2), and in those who were smokers and hypertensive. Therefore, NAFLD is independently associated with CKD progression.Hye Ryoun JangDanbee KangDong Hyun SinnSeonhye GuSoo Jin ChoJung Eun LeeWooseong HuhSeung Woon PaikSeungho RyuYoosoo ChangTariq ShafiMariana LazoEliseo GuallarJuhee ChoGeum-Youn GwakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye Ryoun Jang Danbee Kang Dong Hyun Sinn Seonhye Gu Soo Jin Cho Jung Eun Lee Wooseong Huh Seung Woon Paik Seungho Ryu Yoosoo Chang Tariq Shafi Mariana Lazo Eliseo Guallar Juhee Cho Geum-Youn Gwak Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
description	Abstract This study aimed to investigate the association of nonalcoholic fatty liver disease (NAFLD) and its severity with the decline in kidney function in patients with chronic kidney disease (CKD). We conducted a cohort study of 1,525 CKD patients who underwent repeated health check-up examinations from January 2003 through December 2013. NAFLD was diagnosed by ultrasonography and its severity was assessed by the NAFLD fibrosis score. At baseline, the prevalence of NAFLD was 40.9%, and the mean estimated glomerular filtration rate (eGFR) was 59.1 ml/min/1.73 m2. The average follow-up was 6.5 years. The age- and sex-adjusted decline in eGFR was greater in patients with NAFLD (−0.79% per year, 95% CI −1.31%, −0.27%) compared to those without it (0.30%, 95% CI −0.14%, 0.76%; p = 0.002). In multivariable adjusted models, the average difference in annual percent change in decline in eGFR comparing patients with NAFLD to those without NAFLD was −1.06% (−1.73%, −0.38%; p = 0.002). The decline in eGFR associated with NAFLD was greater in patients with higher NAFLD fibrosis score, in those with proteinuria or with low eGFR at baseline ( <45 ml/min/1.73 m2), and in those who were smokers and hypertensive. Therefore, NAFLD is independently associated with CKD progression.
format	article
author	Hye Ryoun Jang Danbee Kang Dong Hyun Sinn Seonhye Gu Soo Jin Cho Jung Eun Lee Wooseong Huh Seung Woon Paik Seungho Ryu Yoosoo Chang Tariq Shafi Mariana Lazo Eliseo Guallar Juhee Cho Geum-Youn Gwak
author_facet	Hye Ryoun Jang Danbee Kang Dong Hyun Sinn Seonhye Gu Soo Jin Cho Jung Eun Lee Wooseong Huh Seung Woon Paik Seungho Ryu Yoosoo Chang Tariq Shafi Mariana Lazo Eliseo Guallar Juhee Cho Geum-Youn Gwak
author_sort	Hye Ryoun Jang
title	Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
title_short	Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
title_full	Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
title_fullStr	Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
title_full_unstemmed	Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
title_sort	nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/68b43c84612d46d6b74627428f2af9a9
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Nonalcoholic fatty liver disease accelerates kidney function decline in patients with chronic kidney disease: a cohort study

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