Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery

Abstract Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut...

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Autores principales:	Harika Nalluri, Scott Kizy, Kristin Ewing, Girish Luthra, Daniel B. Leslie, David A. Bernlohr, Michael J. Sadowsky, Sayeed Ikramuddin, Alexander Khoruts, Christopher Staley, Cyrus Jahansouz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68b45cb152d840b2a39560c51d673df1
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spelling	oai:doaj.org-article:68b45cb152d840b2a39560c51d673df12021-12-02T16:08:46ZPeri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery10.1038/s41598-020-77285-72045-2322https://doaj.org/article/68b45cb152d840b2a39560c51d673df12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77285-7https://doaj.org/toc/2045-2322Abstract Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating weight loss and resolving associated comorbidities. VSG in humans is a complex procedure and includes peri-operative antibiotics and caloric restriction in addition to the altered anatomy. The impact of each of these factors on the intestinal microbiota have not been evaluated. The aim of this study was to determine the relative contributions of each of these factors on intestinal microbiota composition following VSG prior to substantial weight loss. Thirty-two obese patients underwent one of three treatments: (1) VSG plus routine intravenous peri-operative antibiotics (n = 12), (2) VSG with intravenous vancomycin chosen for its low intestinal penetrance (n = 12), and (3) caloric restriction (n = 8). Fecal samples were evaluated for bacterial composition prior to and 7 days following each intervention. Only patients undergoing VSG with routine peri-operative antibiotics showed a significant shift in community composition. Our data support the single dose of routine peri-operative antibiotics as the most influential factor of intestinal microbial composition acutely following VSG.Harika NalluriScott KizyKristin EwingGirish LuthraDaniel B. LeslieDavid A. BernlohrMichael J. SadowskySayeed IkramuddinAlexander KhorutsChristopher StaleyCyrus JahansouzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Harika Nalluri Scott Kizy Kristin Ewing Girish Luthra Daniel B. Leslie David A. Bernlohr Michael J. Sadowsky Sayeed Ikramuddin Alexander Khoruts Christopher Staley Cyrus Jahansouz Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
description	Abstract Bariatric surgery is the most effective treatment for weight loss. Vertical sleeve gastrectomy (VSG) involves the resection of ~ 80% of the stomach and was conceived to purely restrict oral intake. However, evidence suggests more complex mechanisms, particularly postoperative changes in gut microbiota, in facilitating weight loss and resolving associated comorbidities. VSG in humans is a complex procedure and includes peri-operative antibiotics and caloric restriction in addition to the altered anatomy. The impact of each of these factors on the intestinal microbiota have not been evaluated. The aim of this study was to determine the relative contributions of each of these factors on intestinal microbiota composition following VSG prior to substantial weight loss. Thirty-two obese patients underwent one of three treatments: (1) VSG plus routine intravenous peri-operative antibiotics (n = 12), (2) VSG with intravenous vancomycin chosen for its low intestinal penetrance (n = 12), and (3) caloric restriction (n = 8). Fecal samples were evaluated for bacterial composition prior to and 7 days following each intervention. Only patients undergoing VSG with routine peri-operative antibiotics showed a significant shift in community composition. Our data support the single dose of routine peri-operative antibiotics as the most influential factor of intestinal microbial composition acutely following VSG.
format	article
author	Harika Nalluri Scott Kizy Kristin Ewing Girish Luthra Daniel B. Leslie David A. Bernlohr Michael J. Sadowsky Sayeed Ikramuddin Alexander Khoruts Christopher Staley Cyrus Jahansouz
author_facet	Harika Nalluri Scott Kizy Kristin Ewing Girish Luthra Daniel B. Leslie David A. Bernlohr Michael J. Sadowsky Sayeed Ikramuddin Alexander Khoruts Christopher Staley Cyrus Jahansouz
author_sort	Harika Nalluri
title	Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
title_short	Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
title_full	Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
title_fullStr	Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
title_full_unstemmed	Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
title_sort	peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/68b45cb152d840b2a39560c51d673df1
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Peri-operative antibiotics acutely and significantly impact intestinal microbiota following bariatric surgery

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