Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality

In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2),...

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Autores principales:	Tharwat Imbabi, Islam Sabeq, Ali Osman, Kamal Mahmoud, Shimaa A. Amer, Aziza M. Hassan, Nikolay Kostomakhin, Walid Habashy, Ahmed A. Easa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	weaned rabbits fennel oil apoptosis gene expression meat quality Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/68b523cb0d9e48faa399bc55e9c66be1
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spelling	oai:doaj.org-article:68b523cb0d9e48faa399bc55e9c66be12021-11-25T16:28:45ZImpact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality10.3390/antiox101117972076-3921https://doaj.org/article/68b523cb0d9e48faa399bc55e9c66be12021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1797https://doaj.org/toc/2076-3921In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2), caspase3 (CASP3), and glutathione peroxidase (GPX1) were estimated in the liver tissue using qRT-PCR. A total of 45 Moshtohor weaned male rabbits aged four weeks were randomly allocated to control, T1, and T2 treatment groups; each consisted of 15 weaned male rabbits with five replicates. Rabbits in the T1 and T2 groups were orally supplied with 1 mL fennel oil and 1 mL gentamycin, respectively. Weaned rabbits under different treatments showed increased body weight (BW) at 8 and 12 weeks of age and average daily gain (ADG) at 4–8 and 4–12 weeks of age compared to the control group. Compared to the controls, the weaned rabbits supplemented with fennel oil and gentamycin had lower total cholesterol, triglyceride, and MDA. In addition, villus length, mRNA of BAX, BCL2, Casp3, and GPX were increased in the different treatments compared to the control. Furthermore, the meat of these rabbits was less tender, had a lower aerobic plate count (APC), pH, and was brighter and redder in color than the control. Under the conditions of the present study, the supplementation of weaned Moshtohor rabbits with fennel oil as a natural alternative for gentamycin enhanced feed conversion and daily gain through enhancing villus length and mucus thickness. Additionally, fennel essential oil reduces oxidative stress by increasing the antioxidant enzymes.Tharwat ImbabiIslam SabeqAli OsmanKamal MahmoudShimaa A. AmerAziza M. HassanNikolay KostomakhinWalid HabashyAhmed A. EasaMDPI AGarticleweaned rabbitsfennel oilapoptosisgene expressionmeat qualityTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1797, p 1797 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	weaned rabbits fennel oil apoptosis gene expression meat quality Therapeutics. Pharmacology RM1-950
spellingShingle	weaned rabbits fennel oil apoptosis gene expression meat quality Therapeutics. Pharmacology RM1-950 Tharwat Imbabi Islam Sabeq Ali Osman Kamal Mahmoud Shimaa A. Amer Aziza M. Hassan Nikolay Kostomakhin Walid Habashy Ahmed A. Easa Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
description	In the current study, fennel essential oil was used as an antibiotic alternative compared to gentamycin for enhancing the expression of apoptosis genes and antioxidant enzymes in weaned rabbits as well as meat quality and growth performance. The gene expression of the cell lymphoma 2 (BAX and BCL2), caspase3 (CASP3), and glutathione peroxidase (GPX1) were estimated in the liver tissue using qRT-PCR. A total of 45 Moshtohor weaned male rabbits aged four weeks were randomly allocated to control, T1, and T2 treatment groups; each consisted of 15 weaned male rabbits with five replicates. Rabbits in the T1 and T2 groups were orally supplied with 1 mL fennel oil and 1 mL gentamycin, respectively. Weaned rabbits under different treatments showed increased body weight (BW) at 8 and 12 weeks of age and average daily gain (ADG) at 4–8 and 4–12 weeks of age compared to the control group. Compared to the controls, the weaned rabbits supplemented with fennel oil and gentamycin had lower total cholesterol, triglyceride, and MDA. In addition, villus length, mRNA of BAX, BCL2, Casp3, and GPX were increased in the different treatments compared to the control. Furthermore, the meat of these rabbits was less tender, had a lower aerobic plate count (APC), pH, and was brighter and redder in color than the control. Under the conditions of the present study, the supplementation of weaned Moshtohor rabbits with fennel oil as a natural alternative for gentamycin enhanced feed conversion and daily gain through enhancing villus length and mucus thickness. Additionally, fennel essential oil reduces oxidative stress by increasing the antioxidant enzymes.
format	article
author	Tharwat Imbabi Islam Sabeq Ali Osman Kamal Mahmoud Shimaa A. Amer Aziza M. Hassan Nikolay Kostomakhin Walid Habashy Ahmed A. Easa
author_facet	Tharwat Imbabi Islam Sabeq Ali Osman Kamal Mahmoud Shimaa A. Amer Aziza M. Hassan Nikolay Kostomakhin Walid Habashy Ahmed A. Easa
author_sort	Tharwat Imbabi
title	Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
title_short	Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
title_full	Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
title_fullStr	Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
title_full_unstemmed	Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality
title_sort	impact of fennel essential oil as an antibiotic alternative in rabbit diet on antioxidant enzymes levels, growth performance, and meat quality
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/68b523cb0d9e48faa399bc55e9c66be1
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Impact of Fennel Essential Oil as an Antibiotic Alternative in Rabbit Diet on Antioxidant Enzymes Levels, Growth Performance, and Meat Quality

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