Musical components important for the Mozart K448 effect in epilepsy

Abstract There is growing evidence for the efficacy of music, specifically Mozart’s Sonata for Two Pianos in D Major (K448), at reducing ictal and interictal epileptiform activity. Nonetheless, little is known about the mechanism underlying this beneficial “Mozart K448 effect” for persons with epile...

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Autores principales:	Robert J. Quon, Michael A. Casey, Edward J. Camp, Stephen Meisenhelter, Sarah A. Steimel, Yinchen Song, Markus E. Testorf, Grace A. Leslie, Krzysztof A. Bujarski, Alan B. Ettinger, Barbara C. Jobst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68b55c950b9547759e644858cfd171cd
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spelling	oai:doaj.org-article:68b55c950b9547759e644858cfd171cd2021-12-02T18:02:15ZMusical components important for the Mozart K448 effect in epilepsy10.1038/s41598-021-95922-72045-2322https://doaj.org/article/68b55c950b9547759e644858cfd171cd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95922-7https://doaj.org/toc/2045-2322Abstract There is growing evidence for the efficacy of music, specifically Mozart’s Sonata for Two Pianos in D Major (K448), at reducing ictal and interictal epileptiform activity. Nonetheless, little is known about the mechanism underlying this beneficial “Mozart K448 effect” for persons with epilepsy. Here, we measured the influence that K448 had on intracranial interictal epileptiform discharges (IEDs) in sixteen subjects undergoing intracranial monitoring for refractory focal epilepsy. We found reduced IEDs during the original version of K448 after at least 30-s of exposure. Nonsignificant IED rate reductions were witnessed in all brain regions apart from the bilateral frontal cortices, where we observed increased frontal theta power during transitions from prolonged musical segments. All other presented musical stimuli were associated with nonsignificant IED alterations. These results suggest that the “Mozart K448 effect” is dependent on the duration of exposure and may preferentially modulate activity in frontal emotional networks, providing insight into the mechanism underlying this response. Our findings encourage the continued evaluation of Mozart’s K448 as a noninvasive, non-pharmacological intervention for refractory epilepsy.Robert J. QuonMichael A. CaseyEdward J. CampStephen MeisenhelterSarah A. SteimelYinchen SongMarkus E. TestorfGrace A. LeslieKrzysztof A. BujarskiAlan B. EttingerBarbara C. JobstNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robert J. Quon Michael A. Casey Edward J. Camp Stephen Meisenhelter Sarah A. Steimel Yinchen Song Markus E. Testorf Grace A. Leslie Krzysztof A. Bujarski Alan B. Ettinger Barbara C. Jobst Musical components important for the Mozart K448 effect in epilepsy
description	Abstract There is growing evidence for the efficacy of music, specifically Mozart’s Sonata for Two Pianos in D Major (K448), at reducing ictal and interictal epileptiform activity. Nonetheless, little is known about the mechanism underlying this beneficial “Mozart K448 effect” for persons with epilepsy. Here, we measured the influence that K448 had on intracranial interictal epileptiform discharges (IEDs) in sixteen subjects undergoing intracranial monitoring for refractory focal epilepsy. We found reduced IEDs during the original version of K448 after at least 30-s of exposure. Nonsignificant IED rate reductions were witnessed in all brain regions apart from the bilateral frontal cortices, where we observed increased frontal theta power during transitions from prolonged musical segments. All other presented musical stimuli were associated with nonsignificant IED alterations. These results suggest that the “Mozart K448 effect” is dependent on the duration of exposure and may preferentially modulate activity in frontal emotional networks, providing insight into the mechanism underlying this response. Our findings encourage the continued evaluation of Mozart’s K448 as a noninvasive, non-pharmacological intervention for refractory epilepsy.
format	article
author	Robert J. Quon Michael A. Casey Edward J. Camp Stephen Meisenhelter Sarah A. Steimel Yinchen Song Markus E. Testorf Grace A. Leslie Krzysztof A. Bujarski Alan B. Ettinger Barbara C. Jobst
author_facet	Robert J. Quon Michael A. Casey Edward J. Camp Stephen Meisenhelter Sarah A. Steimel Yinchen Song Markus E. Testorf Grace A. Leslie Krzysztof A. Bujarski Alan B. Ettinger Barbara C. Jobst
author_sort	Robert J. Quon
title	Musical components important for the Mozart K448 effect in epilepsy
title_short	Musical components important for the Mozart K448 effect in epilepsy
title_full	Musical components important for the Mozart K448 effect in epilepsy
title_fullStr	Musical components important for the Mozart K448 effect in epilepsy
title_full_unstemmed	Musical components important for the Mozart K448 effect in epilepsy
title_sort	musical components important for the mozart k448 effect in epilepsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/68b55c950b9547759e644858cfd171cd
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Musical components important for the Mozart K448 effect in epilepsy

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