miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis. It is not yet clear whether miRNAs are able to regulate mitochondrial fission. Here we...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jincheng Li, Stefan Donath, Yanrui Li, Danian Qin, Bellur S Prabhakar, Peifeng Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/68b86122dd8f4f56b330aeb4569276b5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:68b86122dd8f4f56b330aeb4569276b5
record_format	dspace
spelling	oai:doaj.org-article:68b86122dd8f4f56b330aeb4569276b52021-12-02T20:02:29ZmiR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.1553-73901553-740410.1371/journal.pgen.1000795https://doaj.org/article/68b86122dd8f4f56b330aeb4569276b52010-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20062521/?tool=EBIhttps://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis. It is not yet clear whether miRNAs are able to regulate mitochondrial fission. Here we report that miR-30 family members are able to regulate apoptosis by targeting the mitochondrial fission machinery. Our data show that miR-30 family members can inhibit mitochondrial fission and the consequent apoptosis. In exploring the underlying molecular mechanism, we identified that miR-30 family members can suppress p53 expression. In response to the apoptotic stimulation, the expression levels of miR-30 family members were reduced, whereas p53 was upregulated. p53 transcriptionally activated the mitochondrial fission protein, dynamin-related protein-1 (Drp1). The latter conveyed the apoptotic signal of p53 by initiating the mitochondrial fission program. miR-30 family members inhibited mitochondrial fission through suppressing the expression of p53 and its downstream target Drp1. Our data reveal a novel model in which a miRNA can regulate apoptosis through targeting the mitochondrial fission machinery.Jincheng LiStefan DonathYanrui LiDanian QinBellur S PrabhakarPeifeng LiPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 6, Iss 1, p e1000795 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Jincheng Li Stefan Donath Yanrui Li Danian Qin Bellur S Prabhakar Peifeng Li miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
description	miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis. It is not yet clear whether miRNAs are able to regulate mitochondrial fission. Here we report that miR-30 family members are able to regulate apoptosis by targeting the mitochondrial fission machinery. Our data show that miR-30 family members can inhibit mitochondrial fission and the consequent apoptosis. In exploring the underlying molecular mechanism, we identified that miR-30 family members can suppress p53 expression. In response to the apoptotic stimulation, the expression levels of miR-30 family members were reduced, whereas p53 was upregulated. p53 transcriptionally activated the mitochondrial fission protein, dynamin-related protein-1 (Drp1). The latter conveyed the apoptotic signal of p53 by initiating the mitochondrial fission program. miR-30 family members inhibited mitochondrial fission through suppressing the expression of p53 and its downstream target Drp1. Our data reveal a novel model in which a miRNA can regulate apoptosis through targeting the mitochondrial fission machinery.
format	article
author	Jincheng Li Stefan Donath Yanrui Li Danian Qin Bellur S Prabhakar Peifeng Li
author_facet	Jincheng Li Stefan Donath Yanrui Li Danian Qin Bellur S Prabhakar Peifeng Li
author_sort	Jincheng Li
title	miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
title_short	miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
title_full	miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
title_fullStr	miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
title_full_unstemmed	miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
title_sort	mir-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/68b86122dd8f4f56b330aeb4569276b5
work_keys_str_mv	AT jinchengli mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway AT stefandonath mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway AT yanruili mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway AT danianqin mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway AT bellursprabhakar mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway AT peifengli mir30regulatesmitochondrialfissionthroughtargetingp53andthedynaminrelatedprotein1pathway
_version_	1718375665267376128

miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway.

Ejemplares similares