Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.

Recent studies demonstrate that the rate of periodontal breakdown significantly increased in patients compromised from both periodontal disease and osteoporosis. One pharmacological agent used for their treatment is strontium renalate due to its simultaneous ability to increase bone formation and ha...

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Autores principales:	Yufeng Zhang, Lingfei Wei, Chengtie Wu, Richard J Miron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68bb4765a99446b995ed28e9b9c37ba9
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spelling	oai:doaj.org-article:68bb4765a99446b995ed28e9b9c37ba92021-11-25T06:05:03ZPeriodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.1932-620310.1371/journal.pone.0104527https://doaj.org/article/68bb4765a99446b995ed28e9b9c37ba92014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25116811/?tool=EBIhttps://doaj.org/toc/1932-6203Recent studies demonstrate that the rate of periodontal breakdown significantly increased in patients compromised from both periodontal disease and osteoporosis. One pharmacological agent used for their treatment is strontium renalate due to its simultaneous ability to increase bone formation and halt bone resorption. The aim of the present study was to achieve periodontal regeneration of strontium-incorporated mesoporous bioactive glass (Sr-MBG) scaffolds in an osteoporotic animal model carried out by bilateral ovariectomy (OVX). 15 female Wistar rats were randomly assigned to three groups: control unfilled periodontal defects, 2) MBG alone and 3) Sr-MBG scaffolds. 10 weeks after OVX, bilateral fenestration defects were created at the buccal aspect of the first mandibular molar and assessed by micro-CT and histomorphometric analysis after 28 days. Periodontal fenestration defects treated with Sr-MBG scaffolds showed greater new bone formation (46.67%) when compared to MBG scaffolds (39.33%) and control unfilled samples (17.50%). The number of TRAP-positive osteoclasts was also significantly reduced in defects receiving Sr-MBG scaffolds. The results from the present study suggest that Sr-MBG scaffolds may provide greater periondontal regeneration. Clinical studies are required to fully characterize the possible beneficial effect of Sr-releasing scaffolds for patients suffering from a combination of both periodontal disease and osteoporosis.Yufeng ZhangLingfei WeiChengtie WuRichard J MironPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104527 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yufeng Zhang Lingfei Wei Chengtie Wu Richard J Miron Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
description	Recent studies demonstrate that the rate of periodontal breakdown significantly increased in patients compromised from both periodontal disease and osteoporosis. One pharmacological agent used for their treatment is strontium renalate due to its simultaneous ability to increase bone formation and halt bone resorption. The aim of the present study was to achieve periodontal regeneration of strontium-incorporated mesoporous bioactive glass (Sr-MBG) scaffolds in an osteoporotic animal model carried out by bilateral ovariectomy (OVX). 15 female Wistar rats were randomly assigned to three groups: control unfilled periodontal defects, 2) MBG alone and 3) Sr-MBG scaffolds. 10 weeks after OVX, bilateral fenestration defects were created at the buccal aspect of the first mandibular molar and assessed by micro-CT and histomorphometric analysis after 28 days. Periodontal fenestration defects treated with Sr-MBG scaffolds showed greater new bone formation (46.67%) when compared to MBG scaffolds (39.33%) and control unfilled samples (17.50%). The number of TRAP-positive osteoclasts was also significantly reduced in defects receiving Sr-MBG scaffolds. The results from the present study suggest that Sr-MBG scaffolds may provide greater periondontal regeneration. Clinical studies are required to fully characterize the possible beneficial effect of Sr-releasing scaffolds for patients suffering from a combination of both periodontal disease and osteoporosis.
format	article
author	Yufeng Zhang Lingfei Wei Chengtie Wu Richard J Miron
author_facet	Yufeng Zhang Lingfei Wei Chengtie Wu Richard J Miron
author_sort	Yufeng Zhang
title	Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
title_short	Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
title_full	Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
title_fullStr	Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
title_full_unstemmed	Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
title_sort	periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/68bb4765a99446b995ed28e9b9c37ba9
work_keys_str_mv	AT yufengzhang periodontalregenerationusingstrontiumloadedmesoporousbioactiveglassscaffoldsinosteoporoticrats AT lingfeiwei periodontalregenerationusingstrontiumloadedmesoporousbioactiveglassscaffoldsinosteoporoticrats AT chengtiewu periodontalregenerationusingstrontiumloadedmesoporousbioactiveglassscaffoldsinosteoporoticrats AT richardjmiron periodontalregenerationusingstrontiumloadedmesoporousbioactiveglassscaffoldsinosteoporoticrats
_version_	1718414227165675520

Periodontal regeneration using strontium-loaded mesoporous bioactive glass scaffolds in osteoporotic rats.

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