Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study

Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study

Abstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chro...

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Autores principales: Chao Wang, Zhujing Shen, Peiyu Huang, Hualiang Yu, Wei Qian, Xiaojun Guan, Quanquan Gu, Yihong Yang, Minming Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/68bd99ae1ac54a11b607c103c75f02d6
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spelling oai:doaj.org-article:68bd99ae1ac54a11b607c103c75f02d62021-12-02T16:06:30ZAltered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study10.1038/s41598-017-00463-72045-2322https://doaj.org/article/68bd99ae1ac54a11b607c103c75f02d62017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00463-7https://doaj.org/toc/2045-2322Abstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chronic smokers. The aim of this study was to investigate alterations of brain activity during the resting state in chronic smokers using fractional amplitude of low-frequency fluctuation (fALFF). In the present study, 55 smokers and 49 healthy nonsmokers were included. All the subjects underwent resting-state fMRI scans and the data were analyzed by the fALFF approach. The smokers showed significantly decreased fALFF in the left precuneus, right inferior temporal and occipital gyrus(ITG/IOG), while significantly increased fALFF in the right caudate. Subsequent correlation analysis revealed that the fALFF values of the left precuneus and right ITG/IOG were positively correlated with years of smoking across the smokers. This resting-state fMRI study suggests that the changed spontaneous neuronal activity, as reflected by the fALFF, in these regions may be implicated in the underlying the pathophysiology of smoking.Chao WangZhujing ShenPeiyu HuangHualiang YuWei QianXiaojun GuanQuanquan GuYihong YangMinming ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Chao Wang
Zhujing Shen
Peiyu Huang
Hualiang Yu
Wei Qian
Xiaojun Guan
Quanquan Gu
Yihong Yang
Minming Zhang
Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
description Abstract Although a substantial body of previous functional magnetic resonance imaging (fMRI) studies have revealed different brain responses to external stimuli in chronic cigarette smokers compared with nonsmokers, only a few studies assessed brain spontaneous activity in the resting state in chronic smokers. The aim of this study was to investigate alterations of brain activity during the resting state in chronic smokers using fractional amplitude of low-frequency fluctuation (fALFF). In the present study, 55 smokers and 49 healthy nonsmokers were included. All the subjects underwent resting-state fMRI scans and the data were analyzed by the fALFF approach. The smokers showed significantly decreased fALFF in the left precuneus, right inferior temporal and occipital gyrus(ITG/IOG), while significantly increased fALFF in the right caudate. Subsequent correlation analysis revealed that the fALFF values of the left precuneus and right ITG/IOG were positively correlated with years of smoking across the smokers. This resting-state fMRI study suggests that the changed spontaneous neuronal activity, as reflected by the fALFF, in these regions may be implicated in the underlying the pathophysiology of smoking.
format article
author Chao Wang
Zhujing Shen
Peiyu Huang
Hualiang Yu
Wei Qian
Xiaojun Guan
Quanquan Gu
Yihong Yang
Minming Zhang
author_facet Chao Wang
Zhujing Shen
Peiyu Huang
Hualiang Yu
Wei Qian
Xiaojun Guan
Quanquan Gu
Yihong Yang
Minming Zhang
author_sort Chao Wang
title Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
title_short Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
title_full Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
title_fullStr Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
title_full_unstemmed Altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
title_sort altered spontaneous brain activity in chronic smokers revealed by fractional ramplitude of low-frequency fluctuation analysis: a preliminary study
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/68bd99ae1ac54a11b607c103c75f02d6
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