REV7 is required for processing AID initiated DNA lesions in activated B cells

REV7 is required for processing AID initiated DNA lesions in activated B cells

REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.

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Autores principales: Dingpeng Yang, Ying Sun, Jingjing Chen, Ying Zhang, Shuangshuang Fan, Min Huang, Xia Xie, Yanni Cai, Yafang Shang, Tuantuan Gui, Liming Sun, Jiazhi Hu, Junchao Dong, Leng-Siew Yeap, Xiaoming Wang, Wei Xiao, Fei-Long Meng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/68beb3409638444c85e2cc4d0adb4e7d
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spelling oai:doaj.org-article:68beb3409638444c85e2cc4d0adb4e7d2021-12-02T15:57:18ZREV7 is required for processing AID initiated DNA lesions in activated B cells10.1038/s41467-020-16632-82041-1723https://doaj.org/article/68beb3409638444c85e2cc4d0adb4e7d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16632-8https://doaj.org/toc/2041-1723REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.Dingpeng YangYing SunJingjing ChenYing ZhangShuangshuang FanMin HuangXia XieYanni CaiYafang ShangTuantuan GuiLiming SunJiazhi HuJunchao DongLeng-Siew YeapXiaoming WangWei XiaoFei-Long MengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dingpeng Yang
Ying Sun
Jingjing Chen
Ying Zhang
Shuangshuang Fan
Min Huang
Xia Xie
Yanni Cai
Yafang Shang
Tuantuan Gui
Liming Sun
Jiazhi Hu
Junchao Dong
Leng-Siew Yeap
Xiaoming Wang
Wei Xiao
Fei-Long Meng
REV7 is required for processing AID initiated DNA lesions in activated B cells
description REV7 has emerged as a critical regulator of DNA double-strand breaks repair. Here, the authors show that REV7 is crucial for both antibody class switch recombination and somatic hypermutation in activated B cells, in addition to their survival upon AID-deamination.
format article
author Dingpeng Yang
Ying Sun
Jingjing Chen
Ying Zhang
Shuangshuang Fan
Min Huang
Xia Xie
Yanni Cai
Yafang Shang
Tuantuan Gui
Liming Sun
Jiazhi Hu
Junchao Dong
Leng-Siew Yeap
Xiaoming Wang
Wei Xiao
Fei-Long Meng
author_facet Dingpeng Yang
Ying Sun
Jingjing Chen
Ying Zhang
Shuangshuang Fan
Min Huang
Xia Xie
Yanni Cai
Yafang Shang
Tuantuan Gui
Liming Sun
Jiazhi Hu
Junchao Dong
Leng-Siew Yeap
Xiaoming Wang
Wei Xiao
Fei-Long Meng
author_sort Dingpeng Yang
title REV7 is required for processing AID initiated DNA lesions in activated B cells
title_short REV7 is required for processing AID initiated DNA lesions in activated B cells
title_full REV7 is required for processing AID initiated DNA lesions in activated B cells
title_fullStr REV7 is required for processing AID initiated DNA lesions in activated B cells
title_full_unstemmed REV7 is required for processing AID initiated DNA lesions in activated B cells
title_sort rev7 is required for processing aid initiated dna lesions in activated b cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/68beb3409638444c85e2cc4d0adb4e7d
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