From principal component to direct coupling analysis of coevolution in proteins: low-eigenvalue modes are needed for structure prediction.

Various approaches have explored the covariation of residues in multiple-sequence alignments of homologous proteins to extract functional and structural information. Among those are principal component analysis (PCA), which identifies the most correlated groups of residues, and direct coupling analy...

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Autores principales: Simona Cocco, Remi Monasson, Martin Weigt
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/68c16feebb164cbb9f09f23f2fca9ce6
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