Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus

The analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of...

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Autores principales:	Henry Areiza-Laverde, Cindy Dopierala, Lotfi Senhadji, Francois Boucher, Pierre Y. Gumery, Alfredo Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cardiac vibration signals seismocardiogram (SCG) implantable devices biomedical signal processing heart failure Physiology QP1-981
Acceso en línea:	https://doaj.org/article/68c17116070040e2bee180e0f3ac7bac
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spelling	oai:doaj.org-article:68c17116070040e2bee180e0f3ac7bac2021-11-19T07:53:31ZAnalysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus1664-042X10.3389/fphys.2021.748367https://doaj.org/article/68c17116070040e2bee180e0f3ac7bac2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.748367/fullhttps://doaj.org/toc/1664-042XThe analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of the patient to correctly and regularly acquire these signals, remain to be developed. Implantable systems may be a solution to this observability challenge. In this paper, we evaluate the feasibility of acquiring useful electrocardiographic (ECG) and accelerometry (ACC) data from an innovative implant located in the gastric fundus. In a first phase, we compare data acquired from the gastric fundus with gold standard data acquired from surface sensors on 2 pigs. A second phase investigates the feasibility of deriving useful hemodynamic markers from these gastric signals using data from 4 healthy pigs and 3 pigs with induced HF with longitudinal recordings. The following data processing chain was applied to the recordings: (1) ECG and ACC data denoising, (2) noise-robust real-time QRS detection from ECG signals and cardiac cycle segmentation, (3) Correlation analysis of the cardiac cycles and computation of coherent mean from aligned ECG and ACC, (4) cardiac vibration components segmentation (S1 and S2) from the coherent mean ACC data, and (5) estimation of signal context and a signal-to-noise ratio (SNR) on both signals. Results show a high correlation between the markers acquired from the gastric and thoracic sites, as well as pre-clinical evidence on the feasibility of chronic cardiovascular monitoring from an implantable cardiac device located at the gastric fundus, the main challenge remains on the optimization of the signal-to-noise ratio, in particular for the handling of some sources of noise that are specific to the gastric acquisition site.Henry Areiza-LaverdeCindy DopieralaCindy DopieralaLotfi SenhadjiFrancois BoucherPierre Y. GumeryAlfredo HernándezFrontiers Media S.A.articlecardiac vibration signalsseismocardiogram (SCG)implantable devicesbiomedical signal processingheart failurePhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac vibration signals seismocardiogram (SCG) implantable devices biomedical signal processing heart failure Physiology QP1-981
spellingShingle	cardiac vibration signals seismocardiogram (SCG) implantable devices biomedical signal processing heart failure Physiology QP1-981 Henry Areiza-Laverde Cindy Dopierala Cindy Dopierala Lotfi Senhadji Francois Boucher Pierre Y. Gumery Alfredo Hernández Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
description	The analysis of cardiac vibration signals has been shown as an interesting tool for the follow-up of chronic pathologies involving the cardiovascular system, such as heart failure (HF). However, methods to obtain high-quality, real-world and longitudinal data, that do not require the involvement of the patient to correctly and regularly acquire these signals, remain to be developed. Implantable systems may be a solution to this observability challenge. In this paper, we evaluate the feasibility of acquiring useful electrocardiographic (ECG) and accelerometry (ACC) data from an innovative implant located in the gastric fundus. In a first phase, we compare data acquired from the gastric fundus with gold standard data acquired from surface sensors on 2 pigs. A second phase investigates the feasibility of deriving useful hemodynamic markers from these gastric signals using data from 4 healthy pigs and 3 pigs with induced HF with longitudinal recordings. The following data processing chain was applied to the recordings: (1) ECG and ACC data denoising, (2) noise-robust real-time QRS detection from ECG signals and cardiac cycle segmentation, (3) Correlation analysis of the cardiac cycles and computation of coherent mean from aligned ECG and ACC, (4) cardiac vibration components segmentation (S1 and S2) from the coherent mean ACC data, and (5) estimation of signal context and a signal-to-noise ratio (SNR) on both signals. Results show a high correlation between the markers acquired from the gastric and thoracic sites, as well as pre-clinical evidence on the feasibility of chronic cardiovascular monitoring from an implantable cardiac device located at the gastric fundus, the main challenge remains on the optimization of the signal-to-noise ratio, in particular for the handling of some sources of noise that are specific to the gastric acquisition site.
format	article
author	Henry Areiza-Laverde Cindy Dopierala Cindy Dopierala Lotfi Senhadji Francois Boucher Pierre Y. Gumery Alfredo Hernández
author_facet	Henry Areiza-Laverde Cindy Dopierala Cindy Dopierala Lotfi Senhadji Francois Boucher Pierre Y. Gumery Alfredo Hernández
author_sort	Henry Areiza-Laverde
title	Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_short	Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_full	Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_fullStr	Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_full_unstemmed	Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus
title_sort	analysis of cardiac vibration signals acquired from a novel implant placed on the gastric fundus
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/68c17116070040e2bee180e0f3ac7bac
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Analysis of Cardiac Vibration Signals Acquired From a Novel Implant Placed on the Gastric Fundus

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