MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid art...

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Autores principales:	Stefano Alivernini, Mariola Kurowska-Stolarska, Barbara Tolusso, Roberta Benvenuto, Aziza Elmesmari, Silvia Canestri, Luca Petricca, Antonella Mangoni, Anna Laura Fedele, Clara Di Mario, Maria Rita Gigante, Elisa Gremese, Iain B. McInnes, Gianfranco Ferraccioli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68c2c69c5c414557af53643a2120c359
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spelling	oai:doaj.org-article:68c2c69c5c414557af53643a2120c3592021-12-02T15:34:32ZMicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis10.1038/ncomms129702041-1723https://doaj.org/article/68c2c69c5c414557af53643a2120c3592016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12970https://doaj.org/toc/2041-1723MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid arthritis.Stefano AliverniniMariola Kurowska-StolarskaBarbara TolussoRoberta BenvenutoAziza ElmesmariSilvia CanestriLuca PetriccaAntonella MangoniAnna Laura FedeleClara Di MarioMaria Rita GiganteElisa GremeseIain B. McInnesGianfranco FerraccioliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefano Alivernini Mariola Kurowska-Stolarska Barbara Tolusso Roberta Benvenuto Aziza Elmesmari Silvia Canestri Luca Petricca Antonella Mangoni Anna Laura Fedele Clara Di Mario Maria Rita Gigante Elisa Gremese Iain B. McInnes Gianfranco Ferraccioli MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
description	MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid arthritis.
format	article
author	Stefano Alivernini Mariola Kurowska-Stolarska Barbara Tolusso Roberta Benvenuto Aziza Elmesmari Silvia Canestri Luca Petricca Antonella Mangoni Anna Laura Fedele Clara Di Mario Maria Rita Gigante Elisa Gremese Iain B. McInnes Gianfranco Ferraccioli
author_facet	Stefano Alivernini Mariola Kurowska-Stolarska Barbara Tolusso Roberta Benvenuto Aziza Elmesmari Silvia Canestri Luca Petricca Antonella Mangoni Anna Laura Fedele Clara Di Mario Maria Rita Gigante Elisa Gremese Iain B. McInnes Gianfranco Ferraccioli
author_sort	Stefano Alivernini
title	MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
title_short	MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
title_full	MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
title_fullStr	MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
title_full_unstemmed	MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis
title_sort	microrna-155 influences b-cell function through pu.1 in rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/68c2c69c5c414557af53643a2120c359
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MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

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