An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly. Here, the authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-...

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Autores principales: Yang Li, Ping Xie, Liang Lu, Jian Wang, Lihong Diao, Zhongyang Liu, Feifei Guo, Yangzhige He, Yuan Liu, Qin Huang, Han Liang, Dong Li, Fuchu He
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/68c2fe0de1d34e4f89a3fa53d9ff21a4
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spelling oai:doaj.org-article:68c2fe0de1d34e4f89a3fa53d9ff21a42021-12-02T14:42:50ZAn integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network10.1038/s41467-017-00299-92041-1723https://doaj.org/article/68c2fe0de1d34e4f89a3fa53d9ff21a42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00299-9https://doaj.org/toc/2041-1723Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly. Here, the authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-substrate prediction, enabling prediction of the proteome-wide human E3 ligase interaction network.Yang LiPing XieLiang LuJian WangLihong DiaoZhongyang LiuFeifei GuoYangzhige HeYuan LiuQin HuangHan LiangDong LiFuchu HeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Li
Ping Xie
Liang Lu
Jian Wang
Lihong Diao
Zhongyang Liu
Feifei Guo
Yangzhige He
Yuan Liu
Qin Huang
Han Liang
Dong Li
Fuchu He
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
description Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly. Here, the authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-substrate prediction, enabling prediction of the proteome-wide human E3 ligase interaction network.
format article
author Yang Li
Ping Xie
Liang Lu
Jian Wang
Lihong Diao
Zhongyang Liu
Feifei Guo
Yangzhige He
Yuan Liu
Qin Huang
Han Liang
Dong Li
Fuchu He
author_facet Yang Li
Ping Xie
Liang Lu
Jian Wang
Lihong Diao
Zhongyang Liu
Feifei Guo
Yangzhige He
Yuan Liu
Qin Huang
Han Liang
Dong Li
Fuchu He
author_sort Yang Li
title An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
title_short An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
title_full An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
title_fullStr An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
title_full_unstemmed An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network
title_sort integrated bioinformatics platform for investigating the human e3 ubiquitin ligase-substrate interaction network
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/68c2fe0de1d34e4f89a3fa53d9ff21a4
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