Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder

David Isaacs,1 Alexandra P Key,2– 4 Carissa J Cascio,4– 6 Alexander C Conley,2,6 Harrison C Walker,7 Mark T Wallace,3,5,6,8,9 Daniel O Claassen1 1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; 2Center for Cognitive Medicine, Vanderbilt Universi...

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Autores principales:	Isaacs D, Key AP, Cascio CJ, Conley AC, Walker HC, Wallace MT, Claassen DO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	tourette syndrome tic disorder sensory hypersensitivity sensory sensitivity obsessive-compulsive symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/68c619b267d247fb90ee7509f1f770e4
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id	oai:doaj.org-article:68c619b267d247fb90ee7509f1f770e4
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	tourette syndrome tic disorder sensory hypersensitivity sensory sensitivity obsessive-compulsive symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	tourette syndrome tic disorder sensory hypersensitivity sensory sensitivity obsessive-compulsive symptoms Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Isaacs D Key AP Cascio CJ Conley AC Walker HC Wallace MT Claassen DO Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
description	David Isaacs,1 Alexandra P Key,2– 4 Carissa J Cascio,4– 6 Alexander C Conley,2,6 Harrison C Walker,7 Mark T Wallace,3,5,6,8,9 Daniel O Claassen1 1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; 2Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; 3Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA; 4Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN, USA; 5Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA; 6Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 7Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA; 8Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; 9Department of Psychology, Vanderbilt University, Nashville, TN, USACorrespondence: David IsaacsDepartment of Neurology, Vanderbilt University Medical Center, A-0118 Medical Center North, Nashville, TN 37232, USATel +1 615 936-0060Fax +1 615 936-1229Email david.a.isaacs@vumc.orgBackground: Sensory hypersensitivity, defined as heightened awareness of and reactivity to external stimuli, is a bothersome symptom that affects up to 80% of adults with Tourette syndrome (TS). Such widespread prevalence suggests sensory hypersensitivity is a core feature of the disorder, but its severity and association with other clinical features of TS remain largely unexplored. Complicating matters, sensory hypersensitivity has been observed in two neurodevelopmental disorders commonly comorbid with TS: obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD).Objective: We sought to measure sensory hypersensitivity in TS patients relative to healthy controls and to investigate the relationship of sensory hypersensitivity with OCD and ADHD symptoms in the context of TS.Methods: We recruited 34 adults with TS or chronic tic disorder to undergo evaluation with the Yale Global Tic Severity Scale (YGTSS) and a battery of validated self-report instruments assessing sensory hypersensitivity (Sensory Gating Inventory, SGI; Sensory Perception Quotient, SPQ), premonitory urge (Premonitory Urge to Tic Scale, PUTS), OCD (Dimensional Obsessive-Compulsive Scale, DOCS), and ADHD (Adult ADHD Self-Report Screening Scale for DSM-5, ASRS-V). Age- and sex-matched healthy controls were recruited to complete SGI and psychiatric measures.Results: SGI and SPQ scores strongly correlated (rs = − 0.73, p < 0.0001) within patients. SGI total score was significantly higher in patients versus controls (119.0 vs 67.6, U =− 5.3, p < 0.0001), indicating greater sensory hypersensitivity in the tic disorder group. SGI score correlated modestly with PUTS, DOCS, and ASRS-V scores but not with YGTSS total tic score. Hierarchical linear regression analysis revealed that, of the tested variables, only DOCS score contributed significantly to mean SGI score, with β ranging from 1.03 (p = 0.044) to 1.41 (p = 0.001). A simple linear regression model with DOCS as the independent variable accounted for 31.9% of SGI score variance.Conclusion: Sensory hypersensitivity is prominent in adults with tic disorder and is independently associated with obsessive-compulsive symptom severity.Keywords: Tourette syndrome, tic disorder, sensory hypersensitivity, sensory sensitivity, obsessive-compulsive symptoms
format	article
author	Isaacs D Key AP Cascio CJ Conley AC Walker HC Wallace MT Claassen DO
author_facet	Isaacs D Key AP Cascio CJ Conley AC Walker HC Wallace MT Claassen DO
author_sort	Isaacs D
title	Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
title_short	Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
title_full	Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
title_fullStr	Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
title_full_unstemmed	Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder
title_sort	sensory hypersensitivity severity and association with obsessive-compulsive symptoms in adults with tic disorder
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/68c619b267d247fb90ee7509f1f770e4
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spelling	oai:doaj.org-article:68c619b267d247fb90ee7509f1f770e42021-12-02T10:45:08ZSensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder1178-2021https://doaj.org/article/68c619b267d247fb90ee7509f1f770e42020-11-01T00:00:00Zhttps://www.dovepress.com/sensory-hypersensitivity-severity-and-association-with-obsessive-compu-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021David Isaacs,1 Alexandra P Key,2– 4 Carissa J Cascio,4– 6 Alexander C Conley,2,6 Harrison C Walker,7 Mark T Wallace,3,5,6,8,9 Daniel O Claassen1 1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; 2Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; 3Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA; 4Vanderbilt Kennedy Center, Vanderbilt University, Nashville, TN, USA; 5Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA; 6Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 7Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA; 8Department of Pharmacology, Vanderbilt University, Nashville, TN, USA; 9Department of Psychology, Vanderbilt University, Nashville, TN, USACorrespondence: David IsaacsDepartment of Neurology, Vanderbilt University Medical Center, A-0118 Medical Center North, Nashville, TN 37232, USATel +1 615 936-0060Fax +1 615 936-1229Email david.a.isaacs@vumc.orgBackground: Sensory hypersensitivity, defined as heightened awareness of and reactivity to external stimuli, is a bothersome symptom that affects up to 80% of adults with Tourette syndrome (TS). Such widespread prevalence suggests sensory hypersensitivity is a core feature of the disorder, but its severity and association with other clinical features of TS remain largely unexplored. Complicating matters, sensory hypersensitivity has been observed in two neurodevelopmental disorders commonly comorbid with TS: obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD).Objective: We sought to measure sensory hypersensitivity in TS patients relative to healthy controls and to investigate the relationship of sensory hypersensitivity with OCD and ADHD symptoms in the context of TS.Methods: We recruited 34 adults with TS or chronic tic disorder to undergo evaluation with the Yale Global Tic Severity Scale (YGTSS) and a battery of validated self-report instruments assessing sensory hypersensitivity (Sensory Gating Inventory, SGI; Sensory Perception Quotient, SPQ), premonitory urge (Premonitory Urge to Tic Scale, PUTS), OCD (Dimensional Obsessive-Compulsive Scale, DOCS), and ADHD (Adult ADHD Self-Report Screening Scale for DSM-5, ASRS-V). Age- and sex-matched healthy controls were recruited to complete SGI and psychiatric measures.Results: SGI and SPQ scores strongly correlated (rs = − 0.73, p < 0.0001) within patients. SGI total score was significantly higher in patients versus controls (119.0 vs 67.6, U =− 5.3, p < 0.0001), indicating greater sensory hypersensitivity in the tic disorder group. SGI score correlated modestly with PUTS, DOCS, and ASRS-V scores but not with YGTSS total tic score. Hierarchical linear regression analysis revealed that, of the tested variables, only DOCS score contributed significantly to mean SGI score, with β ranging from 1.03 (p = 0.044) to 1.41 (p = 0.001). A simple linear regression model with DOCS as the independent variable accounted for 31.9% of SGI score variance.Conclusion: Sensory hypersensitivity is prominent in adults with tic disorder and is independently associated with obsessive-compulsive symptom severity.Keywords: Tourette syndrome, tic disorder, sensory hypersensitivity, sensory sensitivity, obsessive-compulsive symptomsIsaacs DKey APCascio CJConley ACWalker HCWallace MTClaassen DODove Medical Pressarticletourette syndrometic disordersensory hypersensitivitysensory sensitivityobsessive-compulsive symptomsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2591-2601 (2020)

Sensory Hypersensitivity Severity and Association with Obsessive-Compulsive Symptoms in Adults with Tic Disorder

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