Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is often associated with persistent infections.

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Autores principales:	Alexander Rosenberg, Iuliana V. Ene, Maayan Bibi, Shiri Zakin, Ella Shtifman Segal, Naomi Ziv, Alon M. Dahan, Arnaldo Lopes Colombo, Richard J. Bennett, Judith Berman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68c73745174b466d8c1263316f2a3412
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spelling	oai:doaj.org-article:68c73745174b466d8c1263316f2a34122021-12-02T14:39:26ZAntifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia10.1038/s41467-018-04926-x2041-1723https://doaj.org/article/68c73745174b466d8c1263316f2a34122018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04926-xhttps://doaj.org/toc/2041-1723The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is often associated with persistent infections.Alexander RosenbergIuliana V. EneMaayan BibiShiri ZakinElla Shtifman SegalNaomi ZivAlon M. DahanArnaldo Lopes ColomboRichard J. BennettJudith BermanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander Rosenberg Iuliana V. Ene Maayan Bibi Shiri Zakin Ella Shtifman Segal Naomi Ziv Alon M. Dahan Arnaldo Lopes Colombo Richard J. Bennett Judith Berman Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
description	The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is often associated with persistent infections.
format	article
author	Alexander Rosenberg Iuliana V. Ene Maayan Bibi Shiri Zakin Ella Shtifman Segal Naomi Ziv Alon M. Dahan Arnaldo Lopes Colombo Richard J. Bennett Judith Berman
author_facet	Alexander Rosenberg Iuliana V. Ene Maayan Bibi Shiri Zakin Ella Shtifman Segal Naomi Ziv Alon M. Dahan Arnaldo Lopes Colombo Richard J. Bennett Judith Berman
author_sort	Alexander Rosenberg
title	Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
title_short	Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
title_full	Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
title_fullStr	Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
title_full_unstemmed	Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
title_sort	antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/68c73745174b466d8c1263316f2a3412
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Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

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