Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression...

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Autores principales: Michelle L. Krishnan, Juliette Van Steenwinckel, Anne-Laure Schang, Jun Yan, Johanna Arnadottir, Tifenn Le Charpentier, Zsolt Csaba, Pascal Dournaud, Sara Cipriani, Constance Auvynet, Luigi Titomanlio, Julien Pansiot, Gareth Ball, James P. Boardman, Andrew J. Walley, Alka Saxena, Ghazala Mirza, Bobbi Fleiss, A. David Edwards, Enrico Petretto, Pierre Gressens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/68c92e894f6d4f89971dbd07d7ac5142
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Sumario:Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.

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