Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression...

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Autores principales:	Michelle L. Krishnan, Juliette Van Steenwinckel, Anne-Laure Schang, Jun Yan, Johanna Arnadottir, Tifenn Le Charpentier, Zsolt Csaba, Pascal Dournaud, Sara Cipriani, Constance Auvynet, Luigi Titomanlio, Julien Pansiot, Gareth Ball, James P. Boardman, Andrew J. Walley, Alka Saxena, Ghazala Mirza, Bobbi Fleiss, A. David Edwards, Enrico Petretto, Pierre Gressens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68c92e894f6d4f89971dbd07d7ac5142
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spelling	oai:doaj.org-article:68c92e894f6d4f89971dbd07d7ac51422021-12-02T15:39:03ZIntegrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants10.1038/s41467-017-00422-w2041-1723https://doaj.org/article/68c92e894f6d4f89971dbd07d7ac51422017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00422-whttps://doaj.org/toc/2041-1723Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.Michelle L. KrishnanJuliette Van SteenwinckelAnne-Laure SchangJun YanJohanna ArnadottirTifenn Le CharpentierZsolt CsabaPascal DournaudSara CiprianiConstance AuvynetLuigi TitomanlioJulien PansiotGareth BallJames P. BoardmanAndrew J. WalleyAlka SaxenaGhazala MirzaBobbi FleissA. David EdwardsEnrico PetrettoPierre GressensNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michelle L. Krishnan Juliette Van Steenwinckel Anne-Laure Schang Jun Yan Johanna Arnadottir Tifenn Le Charpentier Zsolt Csaba Pascal Dournaud Sara Cipriani Constance Auvynet Luigi Titomanlio Julien Pansiot Gareth Ball James P. Boardman Andrew J. Walley Alka Saxena Ghazala Mirza Bobbi Fleiss A. David Edwards Enrico Petretto Pierre Gressens Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
description	Inflammation mediated by microglia plays a key role in brain injury associated with preterm birth, but little is known about the microglial response in preterm infants. Here, the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.
format	article
author	Michelle L. Krishnan Juliette Van Steenwinckel Anne-Laure Schang Jun Yan Johanna Arnadottir Tifenn Le Charpentier Zsolt Csaba Pascal Dournaud Sara Cipriani Constance Auvynet Luigi Titomanlio Julien Pansiot Gareth Ball James P. Boardman Andrew J. Walley Alka Saxena Ghazala Mirza Bobbi Fleiss A. David Edwards Enrico Petretto Pierre Gressens
author_facet	Michelle L. Krishnan Juliette Van Steenwinckel Anne-Laure Schang Jun Yan Johanna Arnadottir Tifenn Le Charpentier Zsolt Csaba Pascal Dournaud Sara Cipriani Constance Auvynet Luigi Titomanlio Julien Pansiot Gareth Ball James P. Boardman Andrew J. Walley Alka Saxena Ghazala Mirza Bobbi Fleiss A. David Edwards Enrico Petretto Pierre Gressens
author_sort	Michelle L. Krishnan
title	Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
title_short	Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
title_full	Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
title_fullStr	Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
title_full_unstemmed	Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants
title_sort	integrative genomics of microglia implicates dlg4 (psd95) in the white matter development of preterm infants
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/68c92e894f6d4f89971dbd07d7ac5142
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Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants

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