Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study
Ran Jinnin,1 Yasumasa Okamoto,1 Koki Takagaki,1 Yoshiko Nishiyama,1 Takanao Yamamura,1 Yuri Okamoto,2 Yoshie Miyake,2 Yoshitake Takebayashi,3 Keisuke Tanaka,4 Yoshinori Sugiura,5 Haruki Shimoda,6 Norito Kawakami,6 Toshi A Furukawa,7 Shigeto Yamawaki1 1Department of Psychiatry and Neurosciences, 2Hea...
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Dove Medical Press
2016
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oai:doaj.org-article:68cba5ebcf9443c5bc65b47068bd7ff62021-12-02T00:48:54ZDetailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study1178-2021https://doaj.org/article/68cba5ebcf9443c5bc65b47068bd7ff62016-12-01T00:00:00Zhttps://www.dovepress.com/detailed-course-of-depressive-symptoms-and-risk-for-developing-depress-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ran Jinnin,1 Yasumasa Okamoto,1 Koki Takagaki,1 Yoshiko Nishiyama,1 Takanao Yamamura,1 Yuri Okamoto,2 Yoshie Miyake,2 Yoshitake Takebayashi,3 Keisuke Tanaka,4 Yoshinori Sugiura,5 Haruki Shimoda,6 Norito Kawakami,6 Toshi A Furukawa,7 Shigeto Yamawaki1 1Department of Psychiatry and Neurosciences, 2Health Service Center, Hiroshima University, Hiroshima, Japan; 3Risk Analysis Research Center, The Institute of Statistical Mathematics, Tokyo, Japan; 4Graduated School of Education, Joetsu University of Education, Niigata, Japan; 5Graduated School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan; 6Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 7Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year.Patients and methods: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2,494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II). We conducted a cohort study of three groups (low-, middle-, and high-symptom groups) divided based on BDI-II scores, over a 1 year period with the use of bimonthly assessments. Temporal changes of depressive symptoms were analyzed using linear mixed modeling and growth mixture modeling.Results: First, we found that late adolescents with subthreshold depression (high depressive symptoms) were split between the increasing and decreasing depressive symptoms groups, whereas the majority of the less-symptoms group remained stable during 1 year. Second, in comparison with late adolescents with less depressive symptoms, those with subthreshold depression had an elevated risk of later depression.Conclusion: Some late adolescents with subthreshold depression had increased depressive symptoms and developed an MDE during 1 year. Therefore, it is necessary for us to rigorously assess the changes in subthreshold depressive symptoms over time in late adolescents. Keywords: adolescence, subthreshold depression, major depressive episode, university student, cohort studyJinnin ROkamoto YTakagaki KNishiyama YYamamura TOkamoto YMiyake YTakebayashi YTanaka KSugiura YShimoda HKawakami NFurukawa TAYamawaki SDove Medical PressarticleAdolescenceSubthreshold depressionMajor depressive episodeUniversity studentcohort studyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 25-33 (2016) |
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Adolescence Subthreshold depression Major depressive episode University student cohort study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Adolescence Subthreshold depression Major depressive episode University student cohort study Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jinnin R Okamoto Y Takagaki K Nishiyama Y Yamamura T Okamoto Y Miyake Y Takebayashi Y Tanaka K Sugiura Y Shimoda H Kawakami N Furukawa TA Yamawaki S Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| description |
Ran Jinnin,1 Yasumasa Okamoto,1 Koki Takagaki,1 Yoshiko Nishiyama,1 Takanao Yamamura,1 Yuri Okamoto,2 Yoshie Miyake,2 Yoshitake Takebayashi,3 Keisuke Tanaka,4 Yoshinori Sugiura,5 Haruki Shimoda,6 Norito Kawakami,6 Toshi A Furukawa,7 Shigeto Yamawaki1 1Department of Psychiatry and Neurosciences, 2Health Service Center, Hiroshima University, Hiroshima, Japan; 3Risk Analysis Research Center, The Institute of Statistical Mathematics, Tokyo, Japan; 4Graduated School of Education, Joetsu University of Education, Niigata, Japan; 5Graduated School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan; 6Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 7Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Kyoto, Japan Purpose: Despite its clinical importance, adolescent subthreshold depression remains a largely neglected topic. The aims of this study were to accurately identify the natural course of depressive symptoms and the risk for developing major depressive episode (MDE) in late adolescents with subthreshold depression over 1 year.Patients and methods: One hundred and seventy-two participants <20 years of age (mean age: 18.32 years, standard deviation: 0.50), who did not meet the full criteria for an MDE, were selected from 2,494 screened freshmen based on the Beck Depression Inventory, 2nd edition (BDI-II). We conducted a cohort study of three groups (low-, middle-, and high-symptom groups) divided based on BDI-II scores, over a 1 year period with the use of bimonthly assessments. Temporal changes of depressive symptoms were analyzed using linear mixed modeling and growth mixture modeling.Results: First, we found that late adolescents with subthreshold depression (high depressive symptoms) were split between the increasing and decreasing depressive symptoms groups, whereas the majority of the less-symptoms group remained stable during 1 year. Second, in comparison with late adolescents with less depressive symptoms, those with subthreshold depression had an elevated risk of later depression.Conclusion: Some late adolescents with subthreshold depression had increased depressive symptoms and developed an MDE during 1 year. Therefore, it is necessary for us to rigorously assess the changes in subthreshold depressive symptoms over time in late adolescents. Keywords: adolescence, subthreshold depression, major depressive episode, university student, cohort study |
| format |
article |
| author |
Jinnin R Okamoto Y Takagaki K Nishiyama Y Yamamura T Okamoto Y Miyake Y Takebayashi Y Tanaka K Sugiura Y Shimoda H Kawakami N Furukawa TA Yamawaki S |
| author_facet |
Jinnin R Okamoto Y Takagaki K Nishiyama Y Yamamura T Okamoto Y Miyake Y Takebayashi Y Tanaka K Sugiura Y Shimoda H Kawakami N Furukawa TA Yamawaki S |
| author_sort |
Jinnin R |
| title |
Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| title_short |
Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| title_full |
Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| title_fullStr |
Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| title_full_unstemmed |
Detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| title_sort |
detailed course of depressive symptoms and risk for developing depression in late adolescents with subthreshold depression: a cohort study |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/68cba5ebcf9443c5bc65b47068bd7ff6 |
| work_keys_str_mv |
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| _version_ |
1718403443434979328 |