Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial

<i>Objectives:</i> To compare the possible benefits of the combination of dexamethasone–bupivacaine with articaine–epinephrine as an anaesthetic block after third molar surgery. <i>Materials and Methods:</i> Triple-blind, randomized, controlled, parallel, phase 3 clinical tri...

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Autores principales:	Francisco Javier Quesada-Bravo, Ana Rocío García-Carricondo, Fernando Espín-Gálvez, Carmen Fernández-Sánchez, Damaso Fernández-Ginés, María del Mar Requena-Mullor, Raquel Alarcón-Rodríguez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	third molar surgery bupivacaine dexamethasone submucosa postoperative pain Medicine R
Acceso en línea:	https://doaj.org/article/68cf7bc787834696a1b4358ac6c65471
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spelling	oai:doaj.org-article:68cf7bc787834696a1b4358ac6c654712021-11-11T17:42:06ZComparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial10.3390/jcm102150812077-0383https://doaj.org/article/68cf7bc787834696a1b4358ac6c654712021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5081https://doaj.org/toc/2077-0383<i>Objectives:</i> To compare the possible benefits of the combination of dexamethasone–bupivacaine with articaine–epinephrine as an anaesthetic block after third molar surgery. <i>Materials and Methods:</i> Triple-blind, randomized, controlled, parallel, phase 3 clinical trial. Two groups: experimental (93 patients) with standard anaesthetic block: 40/0.005 mg/mL articaine–epinephrine and submucosal reinforcement with 0.8 mg dexamethasone–5% bupivacaine; and control group (91 patients) with standard block: 40/0.005 mg/mL articaine–epinephrine. The surgery consisted of the extraction of the impacted mandibular third molar by performing a procedure following the same repeatable scheme. The visual analogue scale (VAS) was used to analyse postoperative pain. <i>Results:</i> Groups were homogeneous, without significant differences related to epidemiological variables. Postoperative pain among the first, second, and seventh postoperative days was statistically significantly lower in the experimental group compared to the control group (<i>p</i> < 0.001). Drug consumption was lower in the experimental group throughout the study period (<i>p</i> < 0.04). <i>Conclusion:</i> Bupivacaine is an alternative to articaine in oral surgery, being more effective in reducing postoperative pain by reducing patients’ scores on the VAS as well as their consumption of analgesic drugs after surgery.Francisco Javier Quesada-BravoAna Rocío García-CarricondoFernando Espín-GálvezCarmen Fernández-SánchezDamaso Fernández-GinésMaría del Mar Requena-MullorRaquel Alarcón-RodríguezMDPI AGarticlethird molar surgerybupivacainedexamethasonesubmucosapostoperative painMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5081, p 5081 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	third molar surgery bupivacaine dexamethasone submucosa postoperative pain Medicine R
spellingShingle	third molar surgery bupivacaine dexamethasone submucosa postoperative pain Medicine R Francisco Javier Quesada-Bravo Ana Rocío García-Carricondo Fernando Espín-Gálvez Carmen Fernández-Sánchez Damaso Fernández-Ginés María del Mar Requena-Mullor Raquel Alarcón-Rodríguez Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
description	<i>Objectives:</i> To compare the possible benefits of the combination of dexamethasone–bupivacaine with articaine–epinephrine as an anaesthetic block after third molar surgery. <i>Materials and Methods:</i> Triple-blind, randomized, controlled, parallel, phase 3 clinical trial. Two groups: experimental (93 patients) with standard anaesthetic block: 40/0.005 mg/mL articaine–epinephrine and submucosal reinforcement with 0.8 mg dexamethasone–5% bupivacaine; and control group (91 patients) with standard block: 40/0.005 mg/mL articaine–epinephrine. The surgery consisted of the extraction of the impacted mandibular third molar by performing a procedure following the same repeatable scheme. The visual analogue scale (VAS) was used to analyse postoperative pain. <i>Results:</i> Groups were homogeneous, without significant differences related to epidemiological variables. Postoperative pain among the first, second, and seventh postoperative days was statistically significantly lower in the experimental group compared to the control group (<i>p</i> < 0.001). Drug consumption was lower in the experimental group throughout the study period (<i>p</i> < 0.04). <i>Conclusion:</i> Bupivacaine is an alternative to articaine in oral surgery, being more effective in reducing postoperative pain by reducing patients’ scores on the VAS as well as their consumption of analgesic drugs after surgery.
format	article
author	Francisco Javier Quesada-Bravo Ana Rocío García-Carricondo Fernando Espín-Gálvez Carmen Fernández-Sánchez Damaso Fernández-Ginés María del Mar Requena-Mullor Raquel Alarcón-Rodríguez
author_facet	Francisco Javier Quesada-Bravo Ana Rocío García-Carricondo Fernando Espín-Gálvez Carmen Fernández-Sánchez Damaso Fernández-Ginés María del Mar Requena-Mullor Raquel Alarcón-Rodríguez
author_sort	Francisco Javier Quesada-Bravo
title	Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
title_short	Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
title_full	Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
title_fullStr	Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
title_full_unstemmed	Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial
title_sort	comparative study between the combination of dexamethasone and bupivacaine for third molar surgery postoperative pain: a triple-blind, randomized clinical trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/68cf7bc787834696a1b4358ac6c65471
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Comparative Study between the Combination of Dexamethasone and Bupivacaine for Third Molar Surgery Postoperative Pain: A Triple-Blind, Randomized Clinical Trial

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