Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

Clec4A4 is a C-type lectin receptor highly expressed by CD8α− dendritic cells. Here the authors show that its loss of function results in enhanced T cell responses and exacerbated autoimmunity, implicating Clec4A4 in limiting activation of the CD8α−dendritic cells.

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Autores principales:	Tomofumi Uto, Tomohiro Fukaya, Hideaki Takagi, Keiichi Arimura, Takeshi Nakamura, Naoya Kojima, Bernard Malissen, Katsuaki Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68d74d3b084144968c195f139a3965b8
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spelling	oai:doaj.org-article:68d74d3b084144968c195f139a3965b82021-12-02T14:39:15ZClec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity10.1038/ncomms112732041-1723https://doaj.org/article/68d74d3b084144968c195f139a3965b82016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11273https://doaj.org/toc/2041-1723Clec4A4 is a C-type lectin receptor highly expressed by CD8α− dendritic cells. Here the authors show that its loss of function results in enhanced T cell responses and exacerbated autoimmunity, implicating Clec4A4 in limiting activation of the CD8α−dendritic cells.Tomofumi UtoTomohiro FukayaHideaki TakagiKeiichi ArimuraTakeshi NakamuraNaoya KojimaBernard MalissenKatsuaki SatoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomofumi Uto Tomohiro Fukaya Hideaki Takagi Keiichi Arimura Takeshi Nakamura Naoya Kojima Bernard Malissen Katsuaki Sato Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
description	Clec4A4 is a C-type lectin receptor highly expressed by CD8α− dendritic cells. Here the authors show that its loss of function results in enhanced T cell responses and exacerbated autoimmunity, implicating Clec4A4 in limiting activation of the CD8α−dendritic cells.
format	article
author	Tomofumi Uto Tomohiro Fukaya Hideaki Takagi Keiichi Arimura Takeshi Nakamura Naoya Kojima Bernard Malissen Katsuaki Sato
author_facet	Tomofumi Uto Tomohiro Fukaya Hideaki Takagi Keiichi Arimura Takeshi Nakamura Naoya Kojima Bernard Malissen Katsuaki Sato
author_sort	Tomofumi Uto
title	Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
title_short	Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
title_full	Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
title_fullStr	Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
title_full_unstemmed	Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
title_sort	clec4a4 is a regulatory receptor for dendritic cells that impairs inflammation and t-cell immunity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/68d74d3b084144968c195f139a3965b8
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Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

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