A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the pathological defects observed in CCM.

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Autores principales:	Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras, W. Brent Derry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68d7cbe202d44ec59471ae5b3beec946
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spelling	oai:doaj.org-article:68d7cbe202d44ec59471ae5b3beec9462021-12-02T16:57:24ZA conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis10.1038/s41467-019-09829-z2041-1723https://doaj.org/article/68d7cbe202d44ec59471ae5b3beec9462019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09829-zhttps://doaj.org/toc/2041-1723Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the pathological defects observed in CCM.Eric M. ChapmanBenjamin LantYota OhashiBin YuMichael SchertzbergChristopher GoDeepika DograJanne KoskimäkiRomuald GirardYan LiAndrew G. FraserIssam A. AwadSalim Abdelilah-SeyfriedAnne-Claude GingrasW. Brent DerryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric M. Chapman Benjamin Lant Yota Ohashi Bin Yu Michael Schertzberg Christopher Go Deepika Dogra Janne Koskimäki Romuald Girard Yan Li Andrew G. Fraser Issam A. Awad Salim Abdelilah-Seyfried Anne-Claude Gingras W. Brent Derry A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
description	Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the pathological defects observed in CCM.
format	article
author	Eric M. Chapman Benjamin Lant Yota Ohashi Bin Yu Michael Schertzberg Christopher Go Deepika Dogra Janne Koskimäki Romuald Girard Yan Li Andrew G. Fraser Issam A. Awad Salim Abdelilah-Seyfried Anne-Claude Gingras W. Brent Derry
author_facet	Eric M. Chapman Benjamin Lant Yota Ohashi Bin Yu Michael Schertzberg Christopher Go Deepika Dogra Janne Koskimäki Romuald Girard Yan Li Andrew G. Fraser Issam A. Awad Salim Abdelilah-Seyfried Anne-Claude Gingras W. Brent Derry
author_sort	Eric M. Chapman
title	A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
title_short	A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
title_full	A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
title_fullStr	A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
title_full_unstemmed	A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
title_sort	conserved ccm complex promotes apoptosis non-autonomously by regulating zinc homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/68d7cbe202d44ec59471ae5b3beec946
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A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

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